在人类身上，是否有可能将心脏瘢痕组织转化为跳动的心肌？ - Suppr

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超能文献

Is it possible to transform cardiac scar tissue into beating heart muscle in humans?

作者信息

Chin Michael T, Murry Charles E

出版信息

Regen Med. 2012 Sep;7(5):623-5. doi: 10.2217/rme.12.54.

DOI:10.2217/rme.12.54

PMID:22954430

Abstract

摘要

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Is it possible to transform cardiac scar tissue into beating heart muscle in humans?在人类身上，是否有可能将心脏瘢痕组织转化为跳动的心肌？

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本文引用的文献

Heart repair by reprogramming non-myocytes with cardiac transcription factors.心脏转录因子对非心肌细胞的重编程实现心脏修复。

Nature. 2012 May 13;485(7400):599-604. doi: 10.1038/nature11139.

Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5.使用 Gata4、Mef2c 和 Tbx5 将成纤维细胞低效重编程为心肌细胞。

Circ Res. 2012 Jun 22;111(1):50-5. doi: 10.1161/CIRCRESAHA.112.270264. Epub 2012 May 10.

MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes.microRNA 介导的心肌成纤维细胞体外和体内直接重编程为心肌细胞。

Circ Res. 2012 May 25;110(11):1465-73. doi: 10.1161/CIRCRESAHA.112.269035. Epub 2012 Apr 26.

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.在体重编程鼠心肌成纤维细胞为诱导性心肌细胞。

Nature. 2012 May 31;485(7400):593-8. doi: 10.1038/nature11044.

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial.冠状动脉心脏球源性细胞治疗心肌梗死后的心脏再生（CADUCEUS）：一项前瞻性、随机 1 期试验。

Lancet. 2012 Mar 10;379(9819):895-904. doi: 10.1016/S0140-6736(12)60195-0. Epub 2012 Feb 14.

Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial.缺血性心肌病患者的心脏干细胞（SCIPIO）：一项随机 1 期试验的初步结果。

Lancet. 2011 Nov 26;378(9806):1847-57. doi: 10.1016/S0140-6736(11)61590-0. Epub 2011 Nov 14.

Heart regeneration.心脏再生。

Nature. 2011 May 19;473(7347):326-35. doi: 10.1038/nature10147.

Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy.利用直接重编程策略将小鼠成纤维细胞转化为心肌细胞。

Nat Cell Biol. 2011 Mar;13(3):215-22. doi: 10.1038/ncb2164. Epub 2011 Jan 30.

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.通过定义因子将成纤维细胞直接重编程为功能性心肌细胞。

Cell. 2010 Aug 6;142(3):375-86. doi: 10.1016/j.cell.2010.07.002.

Cellular cardiomyoplasty of cardiac fibroblasts by adenoviral delivery of MyoD ex vivo: an unlimited source of cells for myocardial repair.通过腺病毒在体外递送MyoD对心脏成纤维细胞进行细胞心肌成形术：一种用于心肌修复的无限细胞来源。

Circulation. 2002 Sep 24;106(12 Suppl 1):I125-30.

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