Department of Neurology, INSPE, San Raffaele Scientific Institute, Via Olgettina 48, I-20132 Milan, Italy.
J Clin Neurosci. 2012 Nov;19(11):1582-3. doi: 10.1016/j.jocn.2011.11.040. Epub 2012 Sep 3.
Deep brain stimulation (DBS) can be complicated by adverse events, which are generally classified as surgical-hardware or stimulation-related. Here we report the onset of a painful cervical dystonia probably triggered by the extension wire of a subthalamic nucleus (STN)-DBS device in a woman suffering from advanced Parkinson's disease (PD). Two months after implantation of the STN-DBS device, our patient developed a painful cervical dystonia, which was not responsive to neurostimulation or to medication. No sign of infections or fibrosis was detected. A patch test with the components of the device was performed, revealing no hypersensibility. The patient was referred back to surgery to reposition the pulse generator in the contralateral subclavian region. A deeper channeling of the wire extensions produced a complete remission of the painful dystonia.
脑深部电刺激(DBS)可能会出现不良反应,这些不良反应通常可分为手术相关硬件类和刺激相关类。本文报告了一位晚期帕金森病(PD)女性患者,可能因丘脑底核(STN)-DBS 装置的延长线而引发的疼痛性颈部肌张力障碍。在植入 STN-DBS 装置两个月后,患者出现了疼痛性颈部肌张力障碍,对神经刺激或药物治疗均无反应。未检测到感染或纤维化的迹象。对设备组件进行了斑贴试验,未发现过敏。患者被转至外科手术,将脉冲发生器重新定位到对侧锁骨下区域。对延长线进行更深入的引导后,疼痛性肌张力障碍完全缓解。