Bossart G D, Brawner T A, Cabal C, Kuhns M, Eimstad E A, Caron J, Trimm M, Bradley P
Miami Seaquarium, FL 33149.
J Am Vet Med Assoc. 1990 Jan 1;196(1):127-30.
A Pacific white-sided dolphin (Lagenorhynchus obliquidens) developed clinical signs, serum biochemical values, and serologic viral markers consistent with chronic persistent hepatitis caused by a hepatitis B-like virus. The hepatitis had a sporadic cyclical pattern of lethargy, inappetance, and icterus, with leukocytosis and increased serum activities of alanine transaminase, aspartate transaminase, and gamma-glutamyltransferase. The serum from this dolphin contained hepatitis B virus core antibodies, hepatitis B surface antibodies, and hepatitis B viral DNA. Supportive treatment consisted of administration of antibiotics, cimetidine, menadiol sodium diphosphate, and vitamin/dextrose supplementation. A clinically normal killer whale (Orcinus orca) housed in the same pool had serum hepatitis B surface antibodies, suggesting immunologic responsiveness and that this disease was not species-specific.
一只太平洋白侧海豚（Lagenorhynchus obliquidens）出现了与乙型肝炎样病毒引起的慢性持续性肝炎相符的临床症状、血清生化值和血清学病毒标志物。肝炎呈现出间歇性的周期性模式，表现为嗜睡、食欲不振和黄疸，伴有白细胞增多以及血清丙氨酸转氨酶、天冬氨酸转氨酶和γ-谷氨酰转移酶活性升高。这只海豚的血清中含有乙肝病毒核心抗体、乙肝表面抗体和乙肝病毒DNA。支持性治疗包括使用抗生素、西咪替丁、维生素K4二磷酸酯钠以及补充维生素/葡萄糖。同池饲养的一头临床正常的虎鲸（Orcinus orca）血清中含有乙肝表面抗体，这表明存在免疫反应，且这种疾病并非物种特异性的。
