Department of Medicine, Renal Division, Peking University First Hospital, Beijing, China.
Rheumatology (Oxford). 2012 Dec;51(12):2269-77. doi: 10.1093/rheumatology/kes218. Epub 2012 Sep 6.
The aim of this study was to investigate serum complement factor H (CFH) and its associations with clinical and pathological features in patients with LN.
Serum CFH was detected in 241 LN patients, 38 active and 11 inactive patients with SLE without clinical evidence of renal involvement and 51 normal controls. Serum CFH autoantibodies and CFH Tyr402His were screened in the 241 LN patients. CFH deposition in kidneys was detected in some patients.
Serum CFH levels in patients with LN at active phase were significantly lower than in 38 SLE patients or in normal controls. No serum anti-CFH autoantibodies were detected in patients with LN, and there was no significant difference in CFH Tyr402His distribution between patients with LN and normal controls. Glomerular expression of CFH was stronger than in normal controls. Serum CFH levels were mildly negatively associated with SLEDAI scores (r = -0.204, P = 0.001) and positively associated with serum C3 (r = 0.367, P < 0.001) and haemoglobulin levels (r = 0.193, P = 0.003). Patients with LN class III, subclass IV-S and those with thrombotic microangiopathy had the lowest serum CFH.
Serum CFH levels were associated with disease activity of LN.
本研究旨在探讨狼疮肾炎（LN）患者血清补体因子 H（CFH）及其与临床和病理特征的关系。
检测了 241 例 LN 患者、38 例活动期和 11 例非活动期无肾外临床表现的系统性红斑狼疮（SLE）患者及 51 名正常对照者的血清 CFH。对 241 例 LN 患者进行了血清 CFH 自身抗体和 CFH Tyr402His 的筛查。对部分患者进行了肾脏 CFH 沉积的检测。
活动期 LN 患者的血清 CFH 水平明显低于 38 例 SLE 患者和正常对照组。LN 患者未检测到血清抗 CFH 自身抗体，且 LN 患者与正常对照组 CFH Tyr402His 分布无显著差异。肾小球 CFH 表达强于正常对照组。血清 CFH 水平与 SLEDAI 评分呈轻度负相关（r=-0.204，P=0.001），与血清 C3（r=0.367，P<0.001）和血红蛋白水平（r=0.193，P=0.003）呈正相关。III 型、IV-S 型和血栓性微血管病患者的血清 CFH 水平最低。
血清 CFH 水平与 LN 的疾病活动度有关。
