Li Qiu-Yu, Lv Jian-Min, Liu Xiao-Ling, Li Hai-Yun, Yu Feng
Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.
School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
World J Clin Cases. 2023 May 6;11(13):2934-2944. doi: 10.12998/wjcc.v11.i13.2934.
Complement overactivation is a major driver of lupus nephritis (LN). Impaired interactions of C-reactive protein (CRP) with complement factor H (CFH) have been shown as a pathogenic mechanism that contributes to the overactivation of complement in LN. However, genetic variations of neither CRP nor CFH show consistent influences on the risk of LN.
To examine whether genetic variations of CRP and CFH in combination can improve the risk stratification in Chinese population.
We genotyped six CRP single nucleotide polymorphisms (SNPs) (rs1205, rs3093062, rs2794521, rs1800947, rs3093077, and rs1130864) and three CFH SNPs (rs482934, rs1061170, and rs1061147) in 270 LN patients and 303 healthy subjects.
No linkage was found among CRP and CFH SNPs, indicating lack of genetic interactions between the two genes. Moreover, CRP and CFH SNPs, neither individually nor in combination, are associated with the risk or clinical manifestations of LN. Given the unambiguous pathogenic roles of the two genes.
These findings suggest that the biological effects of most genetic variations of CRP and CFH on their expressions or activities are not sufficient to influence the disease course of LN.
补体过度激活是狼疮性肾炎（LN）的主要驱动因素。C反应蛋白（CRP）与补体因子H（CFH）之间相互作用受损已被证明是导致LN中补体过度激活的一种致病机制。然而，CRP和CFH的基因变异对LN风险均未显示出一致的影响。
研究CRP和CFH的基因变异联合起来是否能改善中国人群的风险分层。
我们对270例LN患者和303名健康受试者的6个CRP单核苷酸多态性（SNP）（rs1205、rs3093062、rs2794521、rs1800947、rs3093077和rs1130864）以及3个CFH SNP（rs482934、rs1061170和rs1061147）进行了基因分型。
未发现CRP和CFH SNP之间存在连锁关系，表明这两个基因之间缺乏基因相互作用。此外，CRP和CFH SNP，无论是单独还是联合，均与LN的风险或临床表现无关。鉴于这两个基因明确的致病作用。
这些发现表明，CRP和CFH的大多数基因变异对其表达或活性的生物学效应不足以影响LN的病程。
