Shimizu T, Chigira M, Nagase M, Watanabe H, Udagawa E
Department of Orthopaedic Surgery, Gunma University School of Medicine, Japan.
J Bone Joint Surg Am. 1990 Jan;72(1):68-70.
Human leukocyte antigen (HLA) phenotypes were studied in twenty Japanese patients who had typical osteosarcoma. The HLA-A11 phenotype was found in ten (50 per cent) of the twenty patients, compared with 16.6 per cent of 235 control subjects (chi square = 13.248; p less than 0.0005)--an odds ratio of 5.026. These data suggest that major histocompatibility complex-linked genes may determine susceptibility to osteosarcoma.
对20例患有典型骨肉瘤的日本患者的人类白细胞抗原（HLA）表型进行了研究。在这20例患者中，有10例（50%）出现了HLA - A11表型，而在235名对照受试者中这一比例为16.6%（卡方检验=13.248；p<0.0005）——优势比为5.026。这些数据表明，主要组织相容性复合体相关基因可能决定对骨肉瘤的易感性。
