Tabacchi P, Chiricolo M, Cenci M, Barboni F, Manfrini M, Bacci G, Picci P, Campanacci M, Licastro F, Franceschi C
Tissue Antigens. 1982 Oct;20(4):251-3. doi: 10.1111/j.1399-0039.1982.tb00353.x.
A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B12 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.
