Syed Sadiqa Badar, Qureshi Masood Anwar
Department of Physiology, Medical and Dental College, Bahria University, Karachi 75260, Pakistan.
Int J Hypertens. 2012;2012:906327. doi: 10.1155/2012/906327. Epub 2012 Aug 16.
Background. The Pakistani population has higher incidence of cardiovascular (CV) diseases at younger ages, due to undiagnosed, uncontrolled hypertension (HTN). A variety of associated HTN stressors is also reported. The study plans to understand the variables associated with initiation of HTN in this population. Objective. To find plasma aldosterone and cortisol relationship with some CV risk factors (obesity, dyslipidemia, hyperglycemia, sodium and potassium) in different stages of HTN particularly prehypertension. Subjects and Methods. The study conducted on 276 subjects (25-60 years), classified into prehypertensive (n = 55), HTN stage-1 (n = 70) and II (n = 76) according to 7th JNC report and compared with normotensive controls (n = 75). The anthropometric profiles (height, weight, waist circumference, Body Mass index) and BP recorded. Serum cortisol, aldosterone, total cholesterol, Low density lipoproteins, blood glucose, Na(+) and K(+), using standard laboratory techniques, were determined in fasting blood samples. Results. Subjects were mostly overweight and obese (80%, 90%, and 76% in pre-HTN, stage-I and II versus 69% in controls). The aldosterone level (ng/dl) was in higher normal range (9.17-12.41) and significantly correlated to BMI (0.587) in controls, and to TC (0.726) and LDL (0.620) in pre-HTN stage-I. The cortisol level was positively correlated (P < 0.01) to BMI (0.538), Na(+) (0.690) and K(+) (0.578) in control, and to BMI (0.628) and WC (0.679) in pre-HTN group, showing its association with BMI > 25. Conclusion. Pre-HTN stage among Pakistani population with successive increase in various risk factors of HTN in relation to aldosterone and cortisol has been identified. Interaction of the risk factors with endogenous levels of these hormones may initiate stages of HTN.
背景。由于未被诊断和控制的高血压（HTN），巴基斯坦人群在较年轻年龄段患心血管（CV）疾病的发生率较高。还报告了多种与高血压相关的应激源。该研究计划了解该人群中与高血压发病相关的变量。目的。在高血压的不同阶段，特别是高血压前期，研究血浆醛固酮和皮质醇与一些心血管危险因素（肥胖、血脂异常、高血糖、钠和钾）之间的关系。对象与方法。该研究对276名受试者（25至60岁）进行，根据美国第七次全国联合委员会（JNC）报告将其分为高血压前期（n = 55）、高血压1期（n = 70）和2期（n = 76），并与血压正常的对照组（n = 75）进行比较。记录人体测量指标（身高、体重、腰围、体重指数）和血压。使用标准实验室技术，测定空腹血样中的血清皮质醇、醛固酮、总胆固醇、低密度脂蛋白、血糖、钠（+）和钾（+）。结果。受试者大多超重和肥胖（高血压前期、1期和2期分别为80%、90%和76%，而对照组为69%）。醛固酮水平（ng/dl）在较高正常范围内（9.17 - 12.41），在对照组中与体重指数（0.587）显著相关，在高血压前期1期与总胆固醇（0.726）和低密度脂蛋白（0.620）显著相关。皮质醇水平在对照组中与体重指数（0.538）、钠（+）（0.690）和钾（+）（0.578）呈正相关（P < 0.01），在高血压前期组中与体重指数（0.628）和腰围（0.679）呈正相关，表明其与体重指数>25有关。结论。已确定巴基斯坦人群中的高血压前期阶段，随着高血压各种危险因素与醛固酮和皮质醇相关联而不断增加。这些危险因素与这些激素内源性水平的相互作用可能引发高血压阶段。
