评价叶下珠地上部分的抗惊厥活性。
Evaluation of anti convulsant activity of aerial parts of Phyllanthus longiflorus heyne ex hook.
机构信息
Department of Pharmaceutical Chemistry, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Tamilnadu, India.
出版信息
Eur Rev Med Pharmacol Sci. 2012 Jul;16 Suppl 3:28-30.
OBJECTIVE
To evaluate anti convulsant effect of aerial parts of Phyllanthus longiflorus (PHL).
MATERIALS AND METHOD
Methanol extract of aerial parts of PHL (MPHL) was prepared by continuous hot extraction method using Soxhlet apparatus. MPHL at the doses 100, 200 and 400 mg/kg were administered to male albino mice by oral route and the activity was assessed against maximal electro shock (MES) and pentylene tetrazole (PTZ) induced seizure. Abolition of hind limb extension and onset of clonic convulsion were taken as a measure of MES and PTZ induced convulsion respectively.
RESULTS
MPHL reduced the duration of extensor phase of convulsion in MES test by 62.5% (at 400 mg/kg) and also delayed the onset of clonic phase of convulsion in PTZ test by 50.7% (at 400 mg/kg). The activity was significant (p < 0.01) and comparable to the reference drug diazepam (2 mg/kg).
CONCLUSION
Results suggest that aerial parts of Phyllanthus longiflorus are useful in the management of convulsion.
目的
评价叶下珠地上部分的抗惊厥作用。
材料与方法
采用索氏提取器连续热提取法制备叶下珠地上部分甲醇提取物（MPHL）。MPHL 以 100、200 和 400 mg/kg 的剂量经口给予雄性白化小鼠，并评估其对最大电休克（MES）和戊四氮（PTZ）诱导的癫痫发作的活性。后肢伸展的消除和阵挛性抽搐的发作被作为 MES 和 PTZ 诱导的惊厥的测量。
结果
MPHL 使 MES 试验中伸展相的持续时间减少了 62.5%（400 mg/kg），并使 PTZ 试验中阵挛相的发作延迟了 50.7%（400 mg/kg）。该活性具有显著性（p < 0.01），与参考药物地西泮（2 mg/kg）相当。
结论
结果表明叶下珠地上部分可用于惊厥的治疗。
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