Rashidian Amir, Kazemi Fatemeh, Mehrzadi Saeed, Dehpour Ahmad Reza, Mehr Shahram Ejtemai, Rezayat Seyed Mahdi
1 Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2 Department of Toxicology and Pharmacology, School of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran.
J Evid Based Complementary Altern Med. 2017 Oct;22(4):632-636. doi: 10.1177/2156587217709930. Epub 2017 Jun 6.
To evaluate the anticonvulsant activity of the aerial parts of Verbena officinalis used traditionally by local Iranians for the treatment of convulsion. The anticonvulsant activity of the extract was assessed in pentylenetetrazole (PTZ) and maximal electroshock (MES) induced seizures in mice. Diazepam was used as reference drug. In addition, for investigating the mechanism of V officinalis in PTZ model, flumazenil and naloxone were injected before V officinalis. The extract showed no toxicity and significantly increased the period taken before the onset and decreased the duration of the seizures induced by PTZ. In the MES test, V officinalis displayed significant reduction in hind limb tonic extension duration in a dose-dependent manner. The results propose that V officinalis ethanolic extract has anticonvulsant activity against seizure. It seems that these effects may be related to potentiating of GABAergic system. Moreover, this study supports the use of this plant by local Iranians in order to treat convulsion.
为评估传统上被伊朗当地人用于治疗惊厥的马鞭草地上部分的抗惊厥活性。在小鼠中，对提取物的抗惊厥活性进行了戊四氮（PTZ）和最大电休克（MES）诱导惊厥的评估。地西泮用作参比药物。此外，为研究马鞭草在PTZ模型中的作用机制，在给予马鞭草之前注射氟马西尼和纳洛酮。提取物无毒性，显著延长了PTZ诱导惊厥发作前的时间，并缩短了惊厥持续时间。在MES试验中，马鞭草以剂量依赖性方式显著缩短后肢强直性伸展持续时间。结果表明，马鞭草乙醇提取物具有抗惊厥活性。这些作用似乎可能与增强GABA能系统有关。此外，本研究支持伊朗当地人使用这种植物来治疗惊厥。
