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减重手术还是 2 型糖尿病药物治疗?

Bariatric surgery or medicine for type 2 diabetes?

机构信息

Queensland University of Technology, School of Biomedical Science, Faculty of Health, QLD4001, Brisbane, Australia.

出版信息

Expert Opin Pharmacother. 2012 Oct;13(15):2249-53. doi: 10.1517/14656566.2012.721779. Epub 2012 Sep 8.

Abstract

Diet and medical treatment are the standard treatment for type 2 diabetes. In obese subjects with type 2 diabetes, bariatric surgery is effective in resolving diabetes. Two clinical trials comparing bariatric surgery to medical treatment were evaluated. Both the Surgical Treatment And Medications Potentially Eradicate Diabetes Efficiently (STAMPEDE) trial (laparoscopic Roux-En Y gastric bypass and sleeve gastrectomy) and the DIet and medical therapy versus BAriatric SurgerY in type 2 diabetes (DIBASY) trial (laparoscopic gastric bypass and biliopancreatic-diversion) showed that surgery was more effective than medical care in resolving or managing type 2 diabetes. Larger studies, or a compilation of studies, are needed to determine whether one of these procedures is better, or if they are all similarly effective, and this should also be weighed against the risk of the operations.

摘要

饮食和医疗是 2 型糖尿病的标准治疗方法。对于 2 型糖尿病肥胖患者,减重手术在解决糖尿病方面是有效的。评估了两项比较减重手术与药物治疗的临床试验。Surgical Treatment And Medications Potentially Eradicate Diabetes Efficiently(STAMPEDE)试验(腹腔镜 Roux-en-Y 胃旁路和袖状胃切除术)和 DIet and medical therapy versus BAriatric SurgerY in type 2 diabetes(DIBASY)试验(腹腔镜胃旁路和胆胰分流术)均表明,手术在解决或控制 2 型糖尿病方面比医疗护理更有效。需要更大规模的研究或研究的综合,以确定这些手术中的一种是否更好,或者它们是否都同样有效,还应该权衡手术的风险。

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