Martinelli P, Sarno L, Maruotti G M, Paludetto R
Department of Obstetrics & Gynaecology, High-Risk Pregnancy Unit, University Federico II of Naples, Naples, Italy.
J Matern Fetal Neonatal Med. 2012 Oct;25 Suppl 4:29-31. doi: 10.3109/14767058.2012.714981.
Chorioamnionitis is the inflammatory response to an acute inflammation of the membranes and chorion of the placenta. We provide a critical review of the relationship between chorioamnionitis and the risk of prematurity and adverse maternal-fetal outcome. Chorioamnionitis results as a major risk factor for preterm birth and its incidence is strictly related to gestational age. It is associated with a significant maternal, perinatal and long-term adverse outcomes. The principal neonatal complications are neonatal sepsis, pneumonia, bronchopulmonary dysplasia, perinatal death, cerebral palsy and intraventricular hemorrhage. The role in neonatal outcome is still controversial and more conclusive studies could clarify the relationship between chorioamnionitis and adverse neonatal outcome. Maternal complications include abnormal progression of labour, caesarean section, postpartum hemorrhage, abnormal response after use of oxytocin and placenta abruption. Prompt administration of antibiotics and steroids could improve neonatal outcomes.
绒毛膜羊膜炎是对胎盘胎膜和绒毛膜急性炎症的炎症反应。我们对绒毛膜羊膜炎与早产风险及母婴不良结局之间的关系进行了批判性综述。绒毛膜羊膜炎是早产的主要危险因素，其发生率与孕周密切相关。它与严重的母体、围产期及长期不良结局相关。主要的新生儿并发症有新生儿败血症、肺炎、支气管肺发育不良、围产期死亡、脑瘫和脑室内出血。其在新生儿结局中的作用仍存在争议，更多确定性研究可能会阐明绒毛膜羊膜炎与不良新生儿结局之间的关系。母体并发症包括产程异常进展、剖宫产、产后出血、使用缩宫素后的异常反应及胎盘早剥。及时使用抗生素和类固醇可改善新生儿结局。
