胎膜早破早产女性组织学绒毛膜羊膜炎、脐带炎与新生儿结局的相关性
The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes.
作者信息
Tsiartas Panagiotis, Kacerovsky Marian, Musilova Ivana, Hornychova Helena, Cobo Teresa, Sävman Karin, Jacobsson Bo
机构信息
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden.
出版信息
J Matern Fetal Neonatal Med. 2013 Sep;26(13):1332-6. doi: 10.3109/14767058.2013.784741. Epub 2013 Apr 16.
OBJECTIVE
To determine the impact of histological chorioamnionitis (HCA) and funisitis on neonatal outcome in preterm prelabor rupture of membranes (PPROM) pregnancies.
METHODS
Women with PPROM between 24 + 0 to 36 + 6 weeks of gestation, admitted to the Department of Obstetrics and Gynecology at the University Hospital Hradec Kralove in the Czech Republic, between July 2008 and October 2010, were enrolled in the study (n = 231).
RESULTS
The incidence of early-onset sepsis (EOS) differed significantly in neonates born to women with and without HCA, after adjustment for gestational age (11% versus 1%, p = 0.011). The incidence of EOS in neonates was also significantly different, after adjustment for gestational age, in cases with and without funisitis (18% versus 4%, p = 0.002). The same was also found for retinopathy of prematurity (ROP) cases with and without funisitis (23% versus 4%, p = 0.014), after adjustment for gestational age.
CONCLUSIONS
HCA and funisitis increase the risk of adverse perinatal outcome in PPROM pregnancies.
目的
确定组织学绒毛膜羊膜炎（HCA）和脐带炎对胎膜早破（PPROM）妊娠新生儿结局的影响。
方法
2008年7月至2010年10月期间，入住捷克共和国赫拉德茨克拉洛韦大学医院妇产科的妊娠24 + 0至36 + 6周的PPROM妇女被纳入研究（n = 231）。
结果
校正胎龄后，患有和未患有HCA的妇女所生新生儿的早发性败血症（EOS）发生率有显著差异（11%对1%，p = 0.011）。校正胎龄后，患有和未患有脐带炎的新生儿EOS发生率也有显著差异（18%对4%，p = 0.002）。校正胎龄后，患有和未患有脐带炎的早产儿视网膜病变（ROP）病例也有同样情况（23%对4%，p = 0.014）。
结论
HCA和脐带炎会增加PPROM妊娠不良围产期结局的风险。
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