University of Pécs, Faculty of Health Sciences, Hungary.
Eur J Obstet Gynecol Reprod Biol. 2012 Aug;163(2):160-4. doi: 10.1016/j.ejogrb.2012.05.012. Epub 2012 Jun 8.
To determine the interaction between histological chorioamnionitis and unexplained neonatal cerebral palsy among low birth weight infants.
We studied 141 preterm infants below 1500 g delivered between 2000 and 2010. Clinical data, neonatal neuroimaging, laboratory results, the histopathological features of the placenta and gastric smear within the first hour of delivery, were evaluated.
Cerebral palsy was detected in 11 out of 141 preterm newborns (7.8%). The incidence of silent histological chorioamnionitis was 33.6% (43 of 128 cases). Chorioamniontis was significantly associated with the risk of unexplained cerebral palsy (p=0.024). There were also significant correlations between maternal genital infections and chorioamnionitis (p=0.005), and between maternal infections and a positive smear of neonatal gastric aspirates (p=0.000). The rate of cesarean section was 67.4% (95 out of 141 deliveries), and elective cesarean section was performed in 68 cases.
Intrauterine exposure to maternal infection was associated with a marked increase in the risk of cerebral palsy in preterm infants.
探讨低体重儿不明原因脑瘫与组织学绒毛膜羊膜炎之间的相互关系。
我们研究了 2000 年至 2010 年间出生的 141 名体重低于 1500 克的早产儿。评估了临床数据、新生儿神经影像学、实验室结果、分娩后 1 小时内胎盘的组织病理学特征和胃抽吸物的胃涂片。
在 141 名早产儿中，有 11 名（7.8%）出现脑瘫。无明显临床症状的组织学绒毛膜羊膜炎发生率为 33.6%（43/128 例）。绒毛膜羊膜炎与不明原因脑瘫的风险显著相关（p=0.024）。产妇生殖道感染与绒毛膜羊膜炎之间（p=0.005）以及产妇感染与新生儿胃抽吸物涂片阳性之间（p=0.000）也存在显著相关性。剖宫产率为 67.4%（141 例分娩中有 95 例），其中 68 例为选择性剖宫产。
宫内暴露于母体感染与早产儿脑瘫风险显著增加有关。
