Risso Francesco M, Sannia Andrea, Gavilanes Danilo A W, Vles Hans J, Colivicchi Micaela, Ricotti Alberto, Li Volti Giovanni, Gazzolo Diego
Department of Neonatology, G Gaslini Children's University Hospital, Genoa, Italy.
J Matern Fetal Neonatal Med. 2012 Oct;25 Suppl 4:101-4. doi: 10.3109/14767058.2012.715024.
There is growing evidence on the usefulness of biomarkers in the early detection of preterm infants at risk for brain damage. However, among different tools Activin A, S100B protein and adrenomedullin assessment offer the possibility to investigate brain/multiorgan function and development. This could be especially useful in perinatal medicine that requires even more non-invasive techniques in order to fulfill the minimal handling in diagnostic and therapeutic strategy performance.
The concept of Unconventional Biological Fluid (UBF: urine and saliva) is becoming even stronger and regards the assessment in non-invasive biological fluids of biochemical markers involved in the cascade of events leading to brain damage.
Activin A, S100B protein and adrenomedullin in UBF were increased in preterm newborns developing brain damage and/or ominous outcome.
The present manuscript offers an update on the usefulness of Activin A, S100B protein an adrenomedullin in UBF as brain damage markers. The findings open a new cue on the use of these markers in daily neonatal intensive care unit (NICU) activities.
越来越多的证据表明生物标志物在早期检测有脑损伤风险的早产儿方面具有实用性。然而，在不同的检测工具中，激活素A、S100B蛋白和肾上腺髓质素评估为研究脑/多器官功能及发育提供了可能。这在围产医学中可能特别有用，因为围产医学需要更多非侵入性技术，以便在诊断和治疗策略实施中实现最小化操作。
非常规生物流体（UBF：尿液和唾液）的概念正变得越来越重要，它涉及对参与导致脑损伤一系列事件的生化标志物在非侵入性生物流体中的评估。
发生脑损伤和/或不良结局的早产儿的UBF中激活素A、S100B蛋白和肾上腺髓质素水平升高。
本手稿提供了关于UBF中激活素A、S100B蛋白和肾上腺髓质素作为脑损伤标志物实用性的最新信息。这些发现为在日常新生儿重症监护病房（NICU）活动中使用这些标志物开辟了新线索。
