Gazzolo Diego, Abella Raul, Frigiola Alessandro, Giamberti Alessandro, Tina Gabriella, Nigro Francesco, Florio Pasquale, Colivicchi Micaela, Temporini Francesca, Ricotti Alberto, Li Volti Giovanni, Galvano Fabio
Department of Maternal, Fetal and Neonatal Medicine, C. Arrigo Children's Hospital, Spalto Marengo 46, Alessandria, Italy.
J Matern Fetal Neonatal Med. 2010 Oct;23 Suppl 3:66-9. doi: 10.3109/14767058.2010.507960.
There is a growing evidence on the use of biomarkers in daily practice both as of markers of brain/multiorgan damage and/or trophic factors. However, among different tools, Activin A, S100B protein, and Hemeoxygenase-1 (HO-1 or Heat Shock Protein 32, HSP32) assessment offer the possibility to investigate brain/multiorgan function and development. This could be especially useful in perinatal medicine that requires even more noninvasive techniques to fulfill the minimal handling diagnostic and therapeutic strategy. In this regard, among different biological fluids, human milk for its unique composition can constitute a wide source of knowledge useful both in clinical daily practice and in research.Therefore, this mini-review reports recent data on the presence and the usefulness of Activin A, S100B protein, and HO-1/HSP32 assessment in human milk as brain/multiorgan development markers. Results open up a new cue on the use of these markers in perinatal medicine as a key protein for investigations focusing on fetal/neonatal development.
越来越多的证据表明，生物标志物在日常实践中可作为脑/多器官损伤标志物和/或营养因子。然而，在不同的检测手段中，激活素A、S100B蛋白和血红素加氧酶-1（HO-1或热休克蛋白32，HSP32）检测为研究脑/多器官功能及发育提供了可能。这在围产医学中可能特别有用，因为围产医学需要更多非侵入性技术来实现最小化操作的诊断和治疗策略。在这方面，在不同生物体液中，人乳因其独特的成分，可成为临床日常实践和研究中广泛的知识来源。因此，本综述报道了人乳中激活素A、S100B蛋白和HO-1/HSP32检测作为脑/多器官发育标志物的最新数据。这些结果为这些标志物在围产医学中的应用开辟了新线索，使其成为专注于胎儿/新生儿发育研究的关键蛋白。
