Institut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Baldiri i Reixac 10, E-08028 Barcelona, Spain.
Structure. 2012 Sep 5;20(9):1448-50. doi: 10.1016/j.str.2012.08.014.
RNA-dependent RNA polymerases (RdRPs) are the central players in both transcription and viral genome replication. Using NMR spectroscopy, Yang and colleagues (in this issue of Structure) show that the conformational changes in the structural motif D of poliovirus RdRP correlate with the nature of the bound nucleotide (correct versus incorrect), with a conserved lysine within this motif playing a key role.
依赖 RNA 的 RNA 聚合酶（RdRPs）是转录和病毒基因组复制的核心参与者。杨等人（本期结构特刊）利用 NMR 光谱学表明，脊髓灰质炎病毒 RdRP 结构基序 D 的构象变化与结合核苷酸的性质（正确与错误）相关，该基序内的一个保守赖氨酸起着关键作用。
