黄病毒RNA合成与复制的调控
Regulation of Flavivirus RNA synthesis and replication.
作者信息
Selisko Barbara, Wang Chunling, Harris Eva, Canard Bruno
机构信息
Aix-Marseille Université, AFMB UMR 7257, 13288 Marseille, France; CNRS, AFMB UMR 7257, 13288 Marseille, France.
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 185 Li Ka Shing Center, Berkeley, CA 94720-3370, USA.
出版信息
Curr Opin Virol. 2014 Dec;9:74-83. doi: 10.1016/j.coviro.2014.09.011. Epub 2014 Oct 17.
Abstract
RNA synthesis and replication of the members of the Flavivirus genus (including dengue, West Nile and Japanese encephalitis viruses) is regulated by a wide variety of mechanisms and actors. These include the sequestration of the RNA-dependent RNA polymerase (RdRp) for functions other than RNA synthesis, regulatory interactions with other viral and host proteins within the replication complex (RC), and regulatory elements within the RNA genome itself. In this review, we discuss our current knowledge of the multiple levels at which Flavivirus RNA synthesis is controlled. We aim to bring together two active research fields: the structural and functional biology of individual proteins of the RC and the impressive wealth of knowledge acquired regarding the viral genomic RNA.
摘要
黄病毒属成员（包括登革热病毒、西尼罗河病毒和日本脑炎病毒）的RNA合成与复制受多种机制和因子调控。这些机制和因子包括将RNA依赖的RNA聚合酶（RdRp）隔离以执行RNA合成以外的功能、与复制复合体（RC）内其他病毒和宿主蛋白的调控相互作用，以及RNA基因组本身的调控元件。在本综述中，我们讨论了目前对黄病毒RNA合成控制的多个层面的认识。我们旨在将两个活跃的研究领域结合起来：RC中单个蛋白质的结构和功能生物学，以及关于病毒基因组RNA所获得的丰富知识。
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