Dana Farber Cancer Institute, Boston MA, USA.
Blood Rev. 2012 Nov;26(6):241-6. doi: 10.1016/j.blre.2012.08.001. Epub 2012 Sep 5.
Only 30% of patients who require an allogeneic hematopoietic cell transplant will have a HLA matched sibling donor. Many patients, particularly those patients with diverse racial and ethnic backgrounds, may not be able to identify a suitably matched unrelated donor. Over 25,000 umbilical cord blood transplant procedures have been performed in the last 25years. Considerable challenges exist in defining the appropriate conditioning regimen and graft vs host disease prophylaxis, surmounting issues of cell dose and delayed engraftment, and improving immune recovery. In this review, we discuss strategies to improve umbilical cord blood transplant outcomes, focusing on cord blood unit selection, expansion, and homing efficiency.
仅有 30%需要异基因造血细胞移植的患者会有 HLA 匹配的同胞供者。许多患者，尤其是那些具有不同种族和民族背景的患者，可能无法识别出合适的匹配无关供者。在过去的 25 年中，已经进行了超过 25000 例脐带血移植手术。在定义适当的预处理方案和移植物抗宿主病预防、克服细胞剂量和延迟植入以及改善免疫恢复方面存在相当大的挑战。在这篇综述中，我们讨论了改善脐带血移植结果的策略，重点是脐带血单位的选择、扩增和归巢效率。
