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尼日利亚拉各斯孕妇对脐血捐献的认知与实践:对尼日利亚未来脐血移植的实践意义。

Awareness and practice of cord blood donation by pregnant women in Lagos Nigeria: Practice implication for future cord blood transplantation in Nigeria.

机构信息

Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Lagos, Nigeria.

Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria.

出版信息

Ann Afr Med. 2021 Jan-Mar;20(1):24-30. doi: 10.4103/aam.aam_9_20.

DOI:10.4103/aam.aam_9_20
PMID:33727508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8102888/
Abstract

BACKGROUND

Poor awareness remains a substantial limitation to harnessing the benefits of umbilical cord blood (UCB) in sub-Saharan Africa. The aim of this study was to determine the level of awareness and factors influencing intention to donate cord blood to blood bank among antenatal clinic attendees at a tertiary hospital in Nigeria.

METHODS

We conducted a questionnaire-based cross-sectional study of 400 women attending the antenatal clinic of a tertiary hospital in Lagos, Nigeria, between February and June 2018. The data were analyzed using Stata version 13; comparisons were conducted with Chi-square, Student's t-test, and Mann-Whitney U-test. Univariable and multivariable binary logistic regression was conducted with "willingness to donate" as the outcome variable.

RESULTS

Majority (n = 287/331 [86.2%, 95% confidence interval [CI]: 76.4-84.9]) of the participants had some knowledge of UCB, almost half intended future donation of UCB (n = 161/333, [48.3%, 95% CI: 42.9-53.6]). Based on our findings, factors such as religion (P = 0.001), education (P = 0.03), information from health-care provider (P < 0.001) appear to influence awareness, and the decision to donate UCB.

CONCLUSION

Although the awareness of the clinical uses of UCB is very limited in Nigeria, the intent to participate in UCB donation is high. Factors such as religion, education, and prior information about UCB donation by health-care providers have been identified in this study to have an influence on the decision to donate UCB.

摘要

背景

在撒哈拉以南非洲,人们对脐带血(UCB)的认识不足仍然是充分利用其益处的一个重大限制。本研究旨在确定尼日利亚一家三级医院产前诊所就诊者对脐带血捐赠到血库的认识水平和影响其捐赠意愿的因素。

方法

我们对 2018 年 2 月至 6 月期间在尼日利亚拉各斯一家三级医院产前诊所就诊的 400 名妇女进行了一项基于问卷的横断面研究。使用 Stata 版本 13 进行数据分析;采用卡方检验、学生 t 检验和曼-惠特尼 U 检验进行比较。采用单变量和多变量二项逻辑回归,以“是否愿意捐赠”作为因变量。

结果

大多数(n = 287/331 [86.2%,95%置信区间[CI]:76.4-84.9])参与者对 UCB 有一定的了解,近一半的人打算将来捐赠 UCB(n = 161/333,[48.3%,95% CI:42.9-53.6])。根据我们的发现,宗教(P = 0.001)、教育(P = 0.03)、来自医疗保健提供者的信息(P < 0.001)等因素似乎影响了人们对 UCB 的认识和捐赠意愿。

结论

尽管尼日利亚对 UCB 的临床用途的认识非常有限,但参与 UCB 捐赠的意愿很高。在这项研究中,宗教、教育以及医疗保健提供者对 UCB 捐赠的先前信息等因素已被确定会影响捐赠 UCB 的决定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf7/8102888/ee0ed3b86259/AAM-20-24-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf7/8102888/437ebf8fa470/AAM-20-24-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf7/8102888/63aa4553de62/AAM-20-24-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf7/8102888/ee0ed3b86259/AAM-20-24-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf7/8102888/437ebf8fa470/AAM-20-24-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf7/8102888/63aa4553de62/AAM-20-24-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf7/8102888/ee0ed3b86259/AAM-20-24-g003.jpg

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本文引用的文献

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3
Knowledge, beliefs, and decisions of pregnant Australian women concerning donation and storage of umbilical cord blood: a population-based survey.
澳大利亚孕妇关于脐带血捐献和储存的知识、信念及决策:一项基于人群的调查。
Birth. 2014 Dec;41(4):360-6. doi: 10.1111/birt.12121. Epub 2014 Jul 2.
4
First successful allogeneic hematopoietic stem cell transplantation for a sickle cell disease patient in a low resource country (Nigeria): a case report.低资源国家(尼日利亚)首例镰状细胞病患者异体造血干细胞移植成功:病例报告
Ann Transplant. 2014 May 5;19:210-3. doi: 10.12659/AOT.890248.
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Improving outcomes in umbilical cord blood transplantation: state of the art.改善脐带血移植的结局:现状。
Blood Rev. 2012 Nov;26(6):241-6. doi: 10.1016/j.blre.2012.08.001. Epub 2012 Sep 5.
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Religious perspectives on umbilical cord blood banking.关于脐带血库的宗教观点。
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