Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
J Colloid Interface Sci. 2012 Nov 15;386(1):421-7. doi: 10.1016/j.jcis.2012.04.031.
Inverted hexagonal blocks of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) lipid adsorbed on a polyethyleneimine (PEI)-coated surface in deionized water transformed its shape upon the application of an electric field, forming lipid objects in a variety of shapes (e.g. lines with a width of 10-50 μm). The phenomenon was driven by the electrophoresis, because the zwitterionic lipid, DOPE turned out to be highly negatively charged in deionized water. The interaction between DOPE and the PEI surface stabilized the system, assuring a lifetime over several weeks for the formed structures after the electric field was switched off. The free-drawing of microscopic objects (lines, crosses, and jelly fish) was also achieved by controlling the direction of the lipid movement with the field direction.
在去离子水中，吸附在聚乙烯亚胺 (PEI) 涂层表面上的 1,2-二油酰基-sn-甘油-3-磷酸乙醇胺 (DOPE) 脂质的六方柱状体在电场的作用下发生了形状变化，形成了各种形状的脂质物体（例如宽度为 10-50μm 的线）。这种现象是由电泳驱动的，因为带电荷的 DOPE 脂质在去离子水中表现出高度的负电荷。DOPE 与 PEI 表面之间的相互作用稳定了该体系，确保了在电场关闭后，形成的结构在数周内保持稳定。通过控制脂质运动的方向，还可以实现微观物体（线、十字和水母）的自由绘制。
