Department of Obstetrics and Gynecology, Hofstra North Shore-LIJ Medical School, New Hyde Park, NY 11040, USA.
Int J Obstet Anesth. 2012 Oct;21(4):324-8. doi: 10.1016/j.ijoa.2012.08.004. Epub 2012 Sep 6.
It was hypothesized that patients who are preload dependent, as demonstrated by a >12% increase in cardiac output in response to a passive leg raise test, would be more likely to exhibit hypotension during spinal anesthesia for cesarean delivery.
Cardiac output response to the passive leg raise test was measured in 40 women before spinal anesthesia with a noninvasive, continuous cardiac output monitor (NICOM®). Patients were divided into two groups based on their performance on the passive leg raise test; those who increased cardiac output >12% following passive leg raise test were considered fluid responsive. NICOM® hemodynamic values were collected from the onset of spinal anesthesia until 10min after delivery of the fetus. The incidence of hypotension, defined as mean arterial blood pressure <70% of the patient's baseline value was compared between the two groups. Vasopressor use, umbilical cord blood gases and Apgar scores were also compared between the groups.
Nine patients were fluid responsive and 31 were fluid non-responsive. The groups had similar demographics and baseline hemodynamic parameters. No significant differences were seen between the groups in the incidence of spinal hypotension, vasopressor use, or neonatal outcome. At the time of delivery, fluid responsive patients had larger cardiac outputs compared to fluid non-responsive patients.
In this pilot study, non-invasive assessment of the hemodynamic response to a volume load was not predictive of hypotension or vasopressor use during cesarean delivery under spinal anesthesia. Fluid responsiveness was related to hemodynamic responses at delivery.
据推测,在接受剖宫产脊髓麻醉时,那些对被动抬腿试验的前负荷反应>12%的患者,更有可能出现低血压。
在接受脊髓麻醉前,使用非侵入性、连续心输出量监测仪(NICOM®)测量 40 名女性对被动抬腿试验的心脏输出量反应。根据被动抬腿试验后的心脏输出量增加情况,将患者分为两组;那些被动抬腿试验后心脏输出量增加>12%的患者被认为是液体反应性的。从脊髓麻醉开始到胎儿娩出后 10 分钟,收集 NICOM®血流动力学值。比较两组低血压(定义为平均动脉压<患者基线值的 70%)的发生率。还比较了两组之间的血管加压药使用、脐动脉血气和 Apgar 评分。
9 例患者为液体反应性,31 例患者为液体无反应性。两组的人口统计学和基线血流动力学参数相似。两组在脊髓低血压的发生率、血管加压药的使用或新生儿结局方面无显著差异。在分娩时,液体反应性患者的心脏输出量大于液体无反应性患者。
在这项初步研究中,对容量负荷反应的非侵入性评估不能预测脊髓麻醉下剖宫产时的低血压或血管加压药的使用。液体反应性与分娩时的血流动力学反应有关。