Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, EH8 9JZ Edinburgh, UK.
Psychoneuroendocrinology. 2013 Apr;38(4):597-601. doi: 10.1016/j.psyneuen.2012.07.018. Epub 2012 Sep 5.
The current study investigated the associations between thyroid stimulating hormone (TSH), free thyroxine (T(4)) and cognitive ability (general ability, memory and processing speed), in a large age homogenous sample (n=659) of generally healthy euthyroid older adults. Associations were considered both at baseline (mean age wave 1=69.5 years; SD=0.8 years) and approximately 3 years later (mean age wave 2=72.5 years; SD=0.7 years). Results indicated mean level decreases across waves in both TSH (t=10.99, p<0.001) and T(4) (t=34.55, p<0.001). There were no significant associations between TSH and T(4) with any of the cognitive variables at either wave. There was no suggestion of non-linear associations. The lack of associations supports suggestions that the effects of thyroid hormones on cognition may be restricted to older individuals above a given threshold, and/or those with levels of thyroid hormones within the range defining clinical thyroid disorder.
本研究调查了促甲状腺激素（TSH）、游离甲状腺素（T4）与认知能力（一般能力、记忆力和处理速度）之间的关联，该研究在一个年龄同质的大型（n=659）一般健康的甲状腺功能正常的老年人样本中进行。在基线时（第 1 波平均年龄=69.5 岁；SD=0.8 岁）和大约 3 年后（第 2 波平均年龄=72.5 岁；SD=0.7 岁）都考虑了关联。结果表明，在两个时间点（TSH：t=10.99，p<0.001；T4：t=34.55，p<0.001），TSH 和 T4 的平均水平均呈下降趋势。在任何一个时间点，TSH 和 T4 与任何认知变量之间均无显著关联。也没有发现非线性关联的迹象。这种关联的缺乏支持了以下观点，即甲状腺激素对认知的影响可能仅限于超过一定阈值的老年人，和/或那些甲状腺激素水平在定义临床甲状腺疾病范围内的人。
