Department of Neurosurgery, the Second People's Hospital of Cixi City, Cixi 315315, China.
Peptides. 2012 Nov;38(1):8-12. doi: 10.1016/j.peptides.2012.08.016. Epub 2012 Aug 30.
Higher plasma visfatin concentration has been associated with ischemic stroke. Thus, we sought to investigate change in plasma visfatin level after traumatic brain injury and to evaluate its relation with disease outcome. Seventy-six healthy controls and 98 patients with acute severe traumatic brain injury were recruited. Twenty-seven patients (27.6%) died and 48 patients (49.0%) suffered from unfavorable outcome (Glasgow outcome scale score of 1-3) in 6 months. On admission, plasma visfatin level was increased in patients than in healthy controls and was highly correlated with Glasgow Coma Scale score. A multivariate analysis identified plasma visfatin level as an independent predictor for 6-month mortality and unfavorable outcome. According to receiver operating characteristic curve analysis, the predictive value of the plasma visfatin concentration was similar to Glasgow Coma Scale score's. In a combined logistic-regression model, visfatin did not improve the predictive value of Glasgow Coma Scale score. Thus, increased plasma visfatin level is associated with 6-month clinical outcomes after severe traumatic brain injury.
较高的血浆内脂素浓度与缺血性中风有关。因此，我们试图研究创伤性脑损伤后血浆内脂素水平的变化，并评估其与疾病结局的关系。招募了 76 名健康对照者和 98 名急性严重创伤性脑损伤患者。27 名患者（27.6%）死亡，48 名患者（49.0%）在 6 个月时预后不良（格拉斯哥结局量表评分为 1-3）。入院时，患者的血浆内脂素水平高于健康对照组，且与格拉斯哥昏迷评分高度相关。多变量分析确定血浆内脂素水平是 6 个月死亡率和预后不良的独立预测因子。根据受试者工作特征曲线分析，血浆内脂素浓度的预测价值与格拉斯哥昏迷评分相似。在联合逻辑回归模型中，内脂素并没有提高格拉斯哥昏迷评分的预测价值。因此，较高的血浆内脂素水平与严重创伤性脑损伤后 6 个月的临床结局相关。
