ABO 血型与卵巢癌协会联盟中上皮性卵巢癌的风险。
ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium.
机构信息
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA.
出版信息
Cancer Causes Control. 2012 Nov;23(11):1805-10. doi: 10.1007/s10552-012-0059-y. Epub 2012 Sep 8.
PURPOSE
Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results.
METHODS
In eight studies participating in the Ovarian Cancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis.
RESULTS
Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI: 0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes.
CONCLUSION
Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.
目的
先前的研究已经检验了 ABO 血型与卵巢癌风险之间的关联，但结果并不一致。
方法
在参与卵巢癌协会联盟的八项研究中，我们通过对 ABO 基因座中的 3 个 SNP 进行基因分型来确定 ABO 血型和单体型。每个研究使用逻辑回归计算优势比和 95%置信区间；使用随机效应荟萃分析合并个体研究结果。
结果
与血型 O 相比，血型 A 与卵巢癌风险适度增加相关：（OR：1.09；95%CI：1.01-1.18；p=0.03）。在单体型分析中，仅 AO 单体型而不是 AA 单体型与风险增加相关（AO：OR：1.11；95%CI：1.01-1.22；p=0.03；AA：OR：1.03；95%CI：0.87-1.21；p=0.76）。AB 型和 B 型均与风险无关。在卵巢癌组织学亚型中，结果相似。
结论
与大多数先前的报告一致，在这项对多个卵巢癌研究的大型分析中，A 血型与卵巢癌风险适度增加相关。需要进一步研究以探讨潜在的生物学机制。
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