Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, China (mainland).
Jilin Province Key Laboratory of Infectious Disease, Laboratory of Molecular Virology, Changchun, Jilin, China (mainland).
Med Sci Monit. 2018 Dec 24;24:9392-9398. doi: 10.12659/MSM.913769.
BACKGROUND The mechanism by which diabetes mellitus (DM) impacts the association between ABO blood types and pancreatic cancer is unclear. MATERIAL AND METHODS A retrospective case-control study of 264 patients with pancreatic cancer and 423 age- and sex-matched individuals with nonmalignant diseases was performed to assess whether ABO blood group and DM jointly contribute to pancreatic cancer risk. RESULTS A multivariate analysis with adjustments for risk factors revealed that blood type, chronic pancreatitis, and DM were significantly associated with increased pancreatic cancer risk. The estimated adjusted odds ratios (AORs with 95% confidence intervals [CIs]) were 2.130 (1.409-3.220) for blood type A, 2.383 (1.313-4.325) for blood type AB, 1.518 (1.012-2.276) for DM, and 10.930 (1.202-99.405) for chronic pancreatitis. Blood type A significantly modified the risk for pancreatic cancer in individuals with DM (AOR, 3.506; 95% CI, 1.659-7.409). CONCLUSIONS The risk for pancreatic cancer was associated with ABO blood type, DM, and chronic pancreatitis in a Chinese population. The risk was greatest for individuals with blood type A and DM.
糖尿病（DM）影响 ABO 血型与胰腺癌之间关联的机制尚不清楚。
对 264 例胰腺癌患者和 423 例年龄和性别匹配的非恶性疾病患者进行了回顾性病例对照研究，以评估 ABO 血型和 DM 是否共同导致胰腺癌风险增加。
经多因素分析调整危险因素后，发现血型、慢性胰腺炎和 DM 与胰腺癌风险增加显著相关。调整后的比值比（95%置信区间）估计值分别为：血型 A 为 2.130（1.409-3.220），血型 AB 为 2.383（1.313-4.325），DM 为 1.518（1.012-2.276），慢性胰腺炎为 10.930（1.202-99.405）。血型 A 在 DM 个体中显著改变了胰腺癌的风险（比值比，3.506；95%置信区间，1.659-7.409）。
在中国人群中，ABO 血型、DM 和慢性胰腺炎与胰腺癌风险相关。血型 A 和 DM 个体的风险最高。
