Reproductive Medicine Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha City, Hunan Province, People's Republic of China.
Clinical Research Center For Women's Reproductive Health In Hunan Province, Changsha, Hunan, China.
Reprod Biol Endocrinol. 2021 Feb 6;19(1):20. doi: 10.1186/s12958-020-00685-x.
There has been an interest in the relationship between ABO blood groups and infertility. Many studies have investigated the association of ABO blood groups with diminished ovarian reserve (DOR), ovarian hyperstimulation syndrome (OHSS), and outcomes of assisted reproductive technology (ART), with controversial results.
A systematic review and meta-analysis was conducted to evaluating the association of ABO blood groups with DOR, OHSS, and outcomes of ART.
Thirteen studies performed between 2010 and 2018 were included in this meta-analysis. DOR, OHSS, live birth rate (LBR), clinical pregnancy rate (CPR), miscarriage rate (MR) were reported in 9, 2, 4, 3, 2 studies, respectively. The combined results showed similar risk of DOR among individuals with blood group A (RR, 0.98; 95% confidence interval [CI], 0.85, 1.13), B (RR, 0.96; 95% CI, 0.76, 1.20), AB (RR, 1.00; 95% CI, 0.76, 1.30), and non-O (RR, 0.94; 95% CI, 0.79, 1.11) as compared to those with blood group O. Meta-analysis showed that the incidences of OHSS were similar in women with blood group A (RR, 1.05; 95% CI, 0.66, 1.66), B (RR, 1.04; 95% CI, 0.46, 2.35), AB (RR, 0.51; 95% CI, 0.10, 2.56), non-O (RR, 1.02; 95% CI, 0.65, 1.57) with blood group O. As to the clinical outcomes, meta-analysis showed no difference in LBR among individuals with blood group A (RR, 1.27; 95% CI, 0.74, 2.17), B (RR, 1.47; 95% CI, 0.95, 2.29), AB (RR, 1.48; 95% CI, 0.76, 2.90), non-O (RR, 1.28; 95% CI, 0.83, 1.98) when compared to those with blood group O. Similarly, the results also found that there were no difference in CPR and MR between women with blood A (CPR: RR, 1.12), B (CPR: RR, 1.08), AB (CPR: RR, 1.05), non-O (CPR: RR, 1.05; MR: RR, 0.94) and blood group O.
ABO blood groups may not be associated with DOR, OHSS, LBR, CPR, and MR of ART. Infertility and ART outcomes are influenced by multiple factors. Blood groups should not be taken into account excessively during diagnosis and treatment of infertile women.
ABO 血型与不孕之间的关系一直受到关注。许多研究调查了 ABO 血型与卵巢储备减少（DOR）、卵巢过度刺激综合征（OHSS）和辅助生殖技术（ART）结局之间的关联，结果存在争议。
系统评价和荟萃分析评估了 ABO 血型与 DOR、OHSS 和 ART 结局的关系。
本荟萃分析纳入了 2010 年至 2018 年期间进行的 13 项研究。9、2、4、3 和 2 项研究分别报告了 DOR、OHSS、活产率（LBR）、临床妊娠率（CPR）和流产率（MR）。综合结果显示，A 型（RR，0.98；95%CI，0.85，1.13）、B 型（RR，0.96；95%CI，0.76，1.20）、AB 型（RR，1.00；95%CI，0.76，1.30）和非 O 型（RR，0.94；95%CI，0.79，1.11）个体的 DOR 风险相似，与 O 型血相比。荟萃分析表明，A 型（RR，1.05；95%CI，0.66，1.66）、B 型（RR，1.04；95%CI，0.46，2.35）、AB 型（RR，0.51；95%CI，0.10，2.56）和非 O 型（RR，1.02；95%CI，0.65，1.57）女性的 OHSS 发生率与 O 型血相似。至于临床结局，荟萃分析显示 A 型（RR，1.27；95%CI，0.74，2.17）、B 型（RR，1.47；95%CI，0.95，2.29）、AB 型（RR，1.48；95%CI，0.76，2.90）和非 O 型（RR，1.28；95%CI，0.83，1.98）个体的 LBR 无差异与 O 型血相比。同样，结果还发现 A 型（CPR：RR，1.12）、B 型（CPR：RR，1.08）、AB 型（CPR：RR，1.05）、非 O 型（CPR：RR，1.05；MR：RR，0.94）与 O 型血的 CPR 和 MR 无差异。
ABO 血型可能与 DOR、OHSS、LBR、CPR 和 ART 的 MR 无关。不孕和 ART 结局受多种因素影响。在诊断和治疗不孕妇女时，不应过分考虑血型。
