EMLA 乳膏对减轻早产儿静脉穿刺疼痛的效果。
The effect of EMLA cream on minimizing pain during venipuncture in premature infants.
机构信息
Department of Nursing, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
出版信息
J Trop Pediatr. 2013 Feb;59(1):72-3. doi: 10.1093/tropej/fms040. Epub 2012 Sep 8.
BACKGROUND
Painful procedures for premature infants in neonatal intensive care units remain inevitable. The goal of this study is to evaluate the effect of an eutectic mixture of local anesthetic (EMLA) cream for minimizing pain in premature infants during venipuncture in neonatal intensive care units.
METHODS
This study enrolled 32 premature infants. A repeated-measures design was used. The scores of the 'Neonatal Pain, Agitation and Sedation Scale' (N-PASS) of each enrolled preterm infant were measured before, during and 10 min after venipuncture without and with EMLA cream use. Paired t-tests were used to compare the difference of N-PASS scores without and with EMLA cream use.
RESULTS
Paired t-tests revealed a significant decrease in N-PASS scores during venipuncture in infants with EMLA cream. There was no significant change of N-PASS scores before, during and 10 min after venipuncture with EMLA cream by analysis of repeated analysis of variance.
CONCLUSION
EMLA cream for minimizing pain during venipuncture could be recommended for premature infants.
背景
新生儿重症监护病房中对早产儿进行有创操作仍然难以避免。本研究旨在评估在新生儿重症监护病房中使用复方利多卡因乳膏减轻早产儿静脉穿刺时疼痛的效果。
方法
本研究纳入了 32 例早产儿。采用重复测量设计。在无和有 EMLA 乳膏使用的情况下，分别于静脉穿刺前、穿刺时和穿刺后 10 分钟，对每个早产儿的“新生儿疼痛、躁动和镇静评分量表（N-PASS）”评分进行测量。采用配对 t 检验比较无和有 EMLA 乳膏使用时 N-PASS 评分的差异。
结果
配对 t 检验显示，在使用 EMLA 乳膏的情况下，静脉穿刺时 N-PASS 评分显著降低。通过重复方差分析，在使用 EMLA 乳膏的情况下，静脉穿刺前、穿刺时和穿刺后 10 分钟的 N-PASS 评分没有显著变化。
结论
对于早产儿，建议在静脉穿刺时使用 EMLA 乳膏以减轻疼痛。
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