Emergency Department, Meyer Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Clin J Pain. 2009 Oct;25(8):711-4. doi: 10.1097/AJP.0b013e3181a689ec.
To examine the efficacy and safety of a new topical anesthetic containing a disinfection ingredient (LidoDin cream) in reducing the pain associated with venipuncture by comparing it with the proven eutectic mixture of lidocaine 2.5% and prilocaine 2.5% (EMLA cream).
A single-blind, randomized, controlled trial was conducted on a study population consisting of a convenience sample of patients aged 12 to 16 years who presented at our Emergency Department between November 2007 and April 2008. The Visual Analog Scale (VAS) was used for pain assessment. Before the study, the bactericidal effect of the LidoDin cream on skin flora was tested.
Twenty patients were enrolled to each arm of the study. Mean patient age was 13.6 years for the LidoDin group and 14.12 years for the EMLA group (P=0.347). Male patients accounted for 55% of the patients in the LidoDin group, compared with 40% in the EMLA group (P=0.527). Skin reaction scores of the LidoDin group for erythema and edema were not statistically different than those of the EMLA group (P=0.73 and P=0.75, respectively). Patient VAS scores and nurse VAS scores of the LidoDin group were not statistically different than those of the EMLA group (P=0.57 and P=0.93, respectively).
This pilot study demonstrated that LidoDin and EMLA seem to be equally safe and effective topical anesthetics for venipuncture. Future studies are planned to determine, if LidoDin reduces the rate of local skin infection in patients treated with multiple daily subcutaneous injections of medications.
通过比较含有消毒成分的新型局部麻醉剂（利多丁乳膏）与已证实的 2.5%利多卡因和 2.5%丙胺卡因的共熔混合物（EMLA 乳膏），研究其在减轻静脉穿刺疼痛方面的疗效和安全性。
这是一项单盲、随机、对照试验，研究对象为 2007 年 11 月至 2008 年 4 月期间在我院急诊科就诊的 12 至 16 岁的便利样本患者。采用视觉模拟评分法（VAS）评估疼痛。在研究之前，测试了利多丁乳膏对皮肤菌群的杀菌效果。
研究中每组各纳入 20 例患者。利多丁组的平均患者年龄为 13.6 岁，EMLA 组为 14.12 岁（P=0.347）。利多丁组的男性患者占 55%，而 EMLA 组为 40%（P=0.527）。利多丁组的皮肤反应评分在红斑和水肿方面与 EMLA 组无统计学差异（P=0.73 和 P=0.75）。利多丁组患者的 VAS 评分和护士的 VAS 评分与 EMLA 组无统计学差异（P=0.57 和 P=0.93）。
这项初步研究表明，利多丁和 EMLA 似乎是两种同样安全有效的静脉穿刺局部麻醉剂。未来的研究计划确定利多丁是否可以降低接受多次每日皮下注射药物治疗的患者局部皮肤感染的发生率。
