Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
Diabetes Care. 2013 Jan;36(1):137-44. doi: 10.2337/dc12-0493. Epub 2012 Sep 6.
To examine whether type 2 diabetes is associated with microstructural abnormalities in specific cerebral white matter tracts and to relate these microstructural abnormalities to cognitive functioning.
Thirty-five nondemented older individuals with type 2 diabetes (mean age 71 ± 5 years) and 35 age-, sex-, and education-matched control subjects underwent a 3 Tesla diffusion-weighted MRI scan and a detailed cognitive assessment. Tractography was performed to reconstruct several white matter tracts. Diffusion tensor imaging measures, including fractional anisotropy (FA) and mean diffusivity (MD), were compared between groups and related to cognitive performance.
MD was significantly increased in all tracts in both hemispheres in patients compared with control subjects (P < 0.05), reflecting microstructural white matter abnormalities in the diabetes group. Increased MD was associated with slowing of information-processing speed and worse memory performance in the diabetes but not in the control group after adjustment for age, sex, and estimated IQ (group × MD interaction, all P < 0.05). These associations were independent of total white matter hyperintensity load and presence of cerebral infarcts.
Individuals with type 2 diabetes showed microstructural abnormalities in various white matter pathways. These abnormalities were related to worse cognitive functioning.
研究 2 型糖尿病是否与特定脑白质束的微观结构异常有关，并将这些微观结构异常与认知功能联系起来。
35 名年龄在 71 ± 5 岁之间的非痴呆 2 型糖尿病患者（平均年龄）和 35 名年龄、性别和教育程度匹配的对照组参与者接受了 3T 弥散加权 MRI 扫描和详细的认知评估。进行了轨迹重建以重建几个白质束。比较了两组之间的弥散张量成像测量值，包括各向异性分数（FA）和平均弥散度（MD），并将其与认知表现相关联。
与对照组相比，患者的所有半球白质束的 MD 均显著增加（P < 0.05），反映了糖尿病组的白质微观结构异常。调整年龄、性别和估计智商后，MD 的增加与糖尿病患者而不是对照组的信息处理速度减慢和记忆表现下降有关（组间×MD 交互作用，均 P < 0.05）。这些关联独立于总白质高信号负荷和脑梗死的存在。
2 型糖尿病患者表现出各种白质通路的微观结构异常。这些异常与认知功能下降有关。
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