Krishna Rahul, Titus Elby, Krishna Rohit, Bardhan Neelkanth, Bahadur Dhirendra, Gracio José
Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
J Nanosci Nanotechnol. 2012 Aug;12(8):6645-51. doi: 10.1166/jnn.2012.4571.
In this paper, we report a novel method for the synthesis of L-Lysine (lys) amino acid coated maghemite (gamma-Fe2O3) magnetic nanoparticles (MNPs). The facile and cost effective method permitted preparation of the high-quality superparamagnetic gamma-Fe2O3 MNPs with hydrophilic and biocompatible nature. For this work, first we synthesized magnetite phase Fe3O4/lys by wet chemical method and oxidized to y-Fe2O3 in controlled oxidizing environment, as evidenced by XRD and VSM magnetometry. The crystallite size and magnetization of gamma-Fe2O3/lys MNPs was found to be 14.5 nm, 40.6 emu/gm respectively. The surface functionalization by L-lysine amino acid and metal-ligand bonding was also confirmed by FTIR spectroscopy. The hydrodynamic diameter, colloidal stability and surface charge on MNPs were characterized by DLS and zeta potential analyser.
在本文中，我们报道了一种合成L-赖氨酸包覆的磁赤铁矿（γ-Fe2O3）磁性纳米颗粒（MNPs）的新方法。这种简便且经济高效的方法能够制备出具有亲水性和生物相容性的高质量超顺磁性γ-Fe2O3 MNPs。在这项工作中，我们首先通过湿化学方法合成了磁铁矿相Fe3O4/赖氨酸，并在可控的氧化环境中氧化为γ-Fe2O3，X射线衍射（XRD）和振动样品磁强计（VSM）测量结果证实了这一点。发现γ-Fe2O3/赖氨酸MNPs的微晶尺寸和磁化强度分别为14.5纳米和40.6电磁单位/克。傅里叶变换红外光谱（FTIR）也证实了L-赖氨酸的表面功能化以及金属-配体键合。通过动态光散射（DLS）和zeta电位分析仪对MNPs的流体动力学直径、胶体稳定性和表面电荷进行了表征。
