Olmsted Medical Center, Rochester, Minnesota 55904, USA.
Am Fam Physician. 2012 Jul 1;86(1):43-50.
Patients with suspected food allergies are commonly seen in clinical practice. Although up to 15 percent of parents believe their children have food allergies, these allergies have been confirmed in only 1 to 3 percent of all Americans. Family physicians must be able to separate true food allergies from food intolerance, food dislikes, and other conditions that mimic food allergy. The most common foods that produce allergic symptoms are milk, eggs, seafood, peanuts, and tree nuts. Although skin testing and in vitro serum immunoglobulin E assays may help in the evaluation of suspected food allergies, they should not be performed unless the clinical history suggests a specific food allergen to which testing can be targeted. Furthermore, these tests do not confirm food allergy. Confirmation requires a positive food challenge or a clear history of an allergic reaction to a food and resolution of symptoms after eliminating that food from the diet. More than 70 percent of children will outgrow milk and egg allergies by early adolescence, whereas peanut allergies usually remain throughout life. The most serious allergic response to food allergy is anaphylaxis. It requires emergency care that should be initiated by the patient or family using an epinephrine autoinjector, which should be carried by anyone with a diagnosed food allergy. These and other recommendations presented in this article are derived from the Guidelines for the Diagnosis and Management of Food Allergy in the United States, published by the National Institute of Allergy and Infectious Diseases.
临床实践中常可见到疑似食物过敏的患者。尽管多达 15%的父母认为其子女有食物过敏,但实际上所有美国人中仅有 1%至 3%的过敏被确诊。家庭医生必须能够将真正的食物过敏与食物不耐受、食物厌恶以及其他类似食物过敏的病症区分开来。最常引起过敏症状的食物是牛奶、鸡蛋、海鲜、花生和坚果。虽然皮肤测试和体外血清免疫球蛋白 E 检测有助于评估疑似食物过敏,但只有当临床病史提示有特定的食物过敏原,且检测可以针对该过敏原时,才应进行这些检测。此外,这些检测并不能确诊食物过敏。确诊需要进行阳性食物激发试验或有明确的食物过敏反应史,且在停止食用该食物后症状得到缓解。超过 70%的儿童在青少年早期会对牛奶和鸡蛋过敏,而花生过敏通常会伴随终生。对食物过敏最严重的过敏反应是过敏反应。它需要紧急护理,应由患者或家属使用肾上腺素自动注射器进行,任何被诊断为食物过敏的人都应携带这种注射器。本文中提出的这些及其他建议源自美国过敏与传染病研究所发布的《美国食物过敏诊断与管理指南》。