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报告两例恶性颗粒细胞瘤患者，并复习文献。

Presentation of two patients with malignant granulosa cell tumors, with a review of the literature.

机构信息

Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, Hirosaki, Japan.

出版信息

World J Surg Oncol. 2012 Sep 11;10:185. doi: 10.1186/1477-7819-10-185.

DOI:10.1186/1477-7819-10-185
PMID:22963202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3490972/
Abstract

Granulosa cell tumors (GCTs) of the ovary account for 2 to 5 of ovarian malignancies. We present two patients with malignant ovarian adult GCT. In one patient, a combination of bleomycin, etoposide, and cisplatin was effective after initial surgery for malignant GCT. In the other, an aromatase inhibitor was effective for recurrent malignant GCT. We also review the literature for further management of this tumor. Because GCT of the ovary is rare, it will be necessary to elucidate the clinical phenotype and establish treatment protocols by accumulating and analyzing more patients.

摘要

卵巢颗粒细胞瘤（GCT）占卵巢恶性肿瘤的 2%至 5%。我们报告了两名患有恶性卵巢成人 GCT 的患者。在一名患者中，博来霉素、依托泊苷和顺铂联合治疗在初次手术治疗恶性 GCT 后有效。在另一名患者中，芳香酶抑制剂对复发性恶性 GCT 有效。我们还回顾了文献，以进一步了解该肿瘤的治疗方法。由于卵巢 GCT 罕见，有必要通过积累和分析更多患者来阐明其临床表型并制定治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7378/3490972/b70e41cdfef4/1477-7819-10-185-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7378/3490972/5375a816b64e/1477-7819-10-185-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7378/3490972/b03248ad4986/1477-7819-10-185-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7378/3490972/29b5e9dc5a25/1477-7819-10-185-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7378/3490972/8807e338dd62/1477-7819-10-185-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7378/3490972/b70e41cdfef4/1477-7819-10-185-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7378/3490972/5375a816b64e/1477-7819-10-185-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7378/3490972/b03248ad4986/1477-7819-10-185-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7378/3490972/29b5e9dc5a25/1477-7819-10-185-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7378/3490972/8807e338dd62/1477-7819-10-185-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7378/3490972/b70e41cdfef4/1477-7819-10-185-5.jpg

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本文引用的文献

1
A late recurring and easily forgotten tumor: ovarian granulosa cell tumor.一种迟发、易被遗忘的肿瘤：卵巢颗粒细胞瘤。
World J Surg Oncol. 2012 May 16;10:85. doi: 10.1186/1477-7819-10-85.
2
Bilateral aggressive malignant granulosa cell tumour with essentially different immunophenotypes in primary and metastatic lesions comprising predominantly sarcomatoid and fibrothecomatous patterns - looking for prognostic markers: a case report.双侧侵袭性恶性颗粒细胞瘤，原发和转移病灶具有截然不同的免疫表型，主要表现为肉瘤样和纤维卵泡膜细胞瘤样形态-寻找预后标志物：一例报告。
Arch Med Sci. 2011 Oct;7(5):918-22. doi: 10.5114/aoms.2011.25573. Epub 2011 Nov 8.
3
Aromatase inhibitors in the treatment of recurrent ovarian granulosa cell tumors: brief report and review of the literature.
芳香化酶抑制剂治疗复发性卵巢颗粒细胞瘤：简要报告及文献综述
J Obstet Gynaecol Res. 2012 Jan;38(1):340-4. doi: 10.1111/j.1447-0756.2011.01698.x. Epub 2011 Dec 5.
4
Promising effect of aromatase inhibitors on recurrent granulosa cell tumors.芳香化酶抑制剂对复发性颗粒细胞瘤有显著疗效。
Int J Gynecol Cancer. 2009 Jul;19(5):830-3. doi: 10.1111/IGC.0b013e3181a261d7.
5
Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial.阿那曲唑与他莫昔芬作为早期乳腺癌辅助治疗的效果：ATAC试验的100个月分析
Lancet Oncol. 2008 Jan;9(1):45-53. doi: 10.1016/S1470-2045(07)70385-6.
6
Granulosa cell tumor of the ovary.卵巢颗粒细胞瘤
Cancer Treat Rev. 2008 Feb;34(1):1-12. doi: 10.1016/j.ctrv.2007.08.007. Epub 2007 Oct 22.
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Characteristics of recurrence in adult-type granulosa cell tumor.成人型颗粒细胞瘤的复发特征。
Int J Gynecol Cancer. 2008 Jul-Aug;18(4):642-7. doi: 10.1111/j.1525-1438.2007.01065.x. Epub 2007 Sep 14.
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Prognostic factors responsible for survival in sex cord stromal tumors of the ovary--an analysis of 376 women.卵巢性索间质肿瘤生存相关的预后因素——376例女性病例分析
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Anastrozole therapy in recurrent ovarian adult granulosa cell tumors: a report of 2 cases.阿那曲唑治疗复发性卵巢成人颗粒细胞瘤：2例报告
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