在高级腺样囊性癌中，P63 阳性/CD117 阳性细胞数量的增加预示着更差的预后。
Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis.
机构信息
Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Dongjiaominxiang No, 1 Dongcheng District, Beijing, China.
出版信息
Diagn Pathol. 2012 Sep 10;7:119. doi: 10.1186/1746-1596-7-119.
OBJECTIVES
This study consisted of two parts. One part was to analyze the survival rates of adenoid cystic carcinoma (ACC) in Chinese and explain the difference between our data and the literature. The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis.
METHODS
A retrospective study of 80 ACC patients was performed. Clinical data were collected, and p63, CD117 were detected by immunohistochemical staining.
RESULTS
Eighty patients received follow-ups 3 to 216 months after initial diagnosis. ACC occurred in the lacrimal gland (26.3%, n = 21), nasal cavity and parasinus (33.8%, n = 27) and other sites (40.0%, n = 33). The 5-year and 10-year survival rates were 66.41% and 10.16%, respectively. Over expression of CD117 was detected in p63-negative cells in 94.3% of cases and in p63-positive cells in 45.8%. The expression of CD117 in p63-positive cells was significantly associated with the histological grade (P<0.001) and prognosis (P = 0.037) in patients in the advanced stage.
CONCLUSIONS
ACC had a good 5-year survival but poor 10-year survival in Chinese, which differed from the occidental data. More p63+/CD117+ cells were associated with a higher histological grade and poorer outcome.
VIRTUAL SLIDES
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1701457278762097.
目的
本研究分为两部分。一部分是分析中国腺样囊性癌（ACC）的生存率，并解释我们的数据与文献之间的差异。另一部分是分析 CD117 的表达与组织学分级和预后的关系。
方法
对 80 例 ACC 患者进行回顾性研究。收集临床资料，采用免疫组织化学染色检测 p63、CD117。
结果
80 例患者在初诊后 3 至 216 个月接受随访。ACC 发生于泪腺（26.3%，n=21）、鼻腔和副鼻窦（33.8%，n=27）和其他部位（40.0%，n=33）。5 年和 10 年生存率分别为 66.41%和 10.16%。94.3%的病例中 p63 阴性细胞中检测到 CD117 过表达，45.8%的病例中 p63 阳性细胞中检测到 CD117 过表达。CD117 在 p63 阳性细胞中的表达与晚期患者的组织学分级（P<0.001）和预后（P=0.037）显著相关。
结论
中国人 ACC 的 5 年生存率较好，但 10 年生存率较差，与西方数据不同。更多的 p63+/CD117+细胞与较高的组织学分级和较差的预后相关。
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