Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
J Am Chem Soc. 2012 Sep 19;134(37):15305-8. doi: 10.1021/ja308009g. Epub 2012 Sep 11.
α-Aminonitriles inaccessible by traditional Strecker chemistry are obtained in redox-neutral fashion by direct amine α-cyanation/N-alkylation or alternatively, α-aminonitrile isomerization. These unprecedented transformations are catalyzed by simple carboxylic acids.
通过传统的Strecker 化学无法获得的α-氨基腈以氧化还原中性的方式通过直接胺α-氰化/N-烷基化或替代地，α-氨基腈异构化获得。这些前所未有的转化由简单的羧酸催化。
