Chinese Center for Disease Control and Prevention, Beijing, China.
Int J Tuberc Lung Dis. 2012 Nov;16(11):1485-91. doi: 10.5588/ijtld.12.0193. Epub 2012 Sep 7.
Health care workers (HCWs) are at increased risk for tuberculosis (TB) infection. In China, surveys examining TB infection among HCWs have not studied general health care facilities, compared tuberculin tests conducted using local protocols against an internationally accepted test or characterised risk factors.
To measure the prevalence of and risk factors for TB infection among HCWs in Inner Mongolia, China.
Between April and August 2010, we administered QuantiFERON®-TB Gold In-Tube (QFT-GIT) tests, skin tests using Chinese tuberculin (TST) and surveys among HCWs at an infectious diseases hospital and a general medical hospital. We assessed whether demographic characteristics, personal exposure and work exposure were associated with QFT-GIT and TST positivity, and assessed agreement between test results.
Of 999 HCWs, 683 (68%) were QFT-GIT-positive, which was associated with greater age, longer HCW career, TB disease in a co-worker and greater daily patient exposure using multivariable analysis. TST reactions ≥ 5 mm occurred in 69% of the HCWs; agreement between test results was low ( 0.22).
The prevalence of TB infection among HCWs in Inner Mongolia is high; infection was associated with occupational exposure. Results from locally conducted TST are difficult to interpret. In China, TB infection control in health care facilities should be strengthened.
医护人员（HCWs）感染结核病（TB）的风险增加。在中国，调查研究 HCWs 中 TB 感染的研究并未涉及一般医疗保健机构，也没有使用当地方案进行的结核菌素试验与国际公认的试验进行比较，也没有对危险因素进行描述。
测量中国内蒙古地区 HCWs 中 TB 感染的流行率和危险因素。
在 2010 年 4 月至 8 月期间，我们对传染病医院和综合医院的 HCWs 进行了 QuantiFERON®-TB Gold In-Tube（QFT-GIT）测试、使用中国结核菌素（TST）的皮肤测试和调查。我们评估了人口统计学特征、个人暴露和工作暴露与 QFT-GIT 和 TST 阳性之间的关系，并评估了测试结果之间的一致性。
在 999 名 HCWs 中，683 名（68%）为 QFT-GIT 阳性，多变量分析显示，这与年龄较大、HCW 职业时间较长、同事中有 TB 病和每天接触更多患者有关。TST 反应≥5mm 发生在 69%的 HCWs 中；测试结果之间的一致性较低（ 0.22）。
内蒙古地区 HCWs 中 TB 感染的流行率很高；感染与职业暴露有关。当地进行的 TST 结果难以解释。在中国，应加强医疗机构的 TB 感染控制。
