KPC-9，一种来自以色列临床样本中的新型碳青霉烯酶。
KPC-9, a novel carbapenemase from clinical specimens in Israel.
机构信息
Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
出版信息
Antimicrob Agents Chemother. 2012 Nov;56(11):6057-9. doi: 10.1128/AAC.01156-12. Epub 2012 Sep 10.
Abstract
A bla(KPC-9) carbapenemase variant was discovered in isolates of Klebsiella pneumoniae and Escherichia coli from a single patient. It differed from bla(KPC-3) by one amino acid substitution (Val239Ala). The K. pneumoniae isolate was typed as ST258, as was the epidemic Israeli KPC-3 clone. bla(KPC-9) was found on a plasmid indistinguishable from pKpQIL that carries bla(KPC-3) in the epidemic clone. Compared to KPC-3, KPC-9 conferred less resistance to carbapenems and higher resistance to ceftazidime.
摘要
一种 bla(KPC-9)碳青霉烯酶变体在来自单一患者的肺炎克雷伯菌和大肠杆菌分离株中被发现。它与 bla(KPC-3) 仅差一个氨基酸取代（Val239Ala）。肺炎克雷伯菌分离株的型别为 ST258，与流行的以色列 KPC-3 克隆株相同。bla(KPC-9) 位于与在流行克隆株中携带 bla(KPC-3) 的 pKpQIL 无法区分的质粒上。与 KPC-3 相比，KPC-9 对碳青霉烯类的耐药性较低，对头孢他啶的耐药性较高。
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