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Early in vitro development of daptomycin non-susceptibility in high-level aminoglycoside-resistant Enterococcus faecalis predicts the efficacy of the combination of high-dose daptomycin plus ampicillin in an in vivo model of experimental endocarditis.在高水平氨基糖苷类耐药粪肠球菌中，达托霉素不敏感性的早期体外发展可预测在实验性心内膜炎体内模型中高剂量达托霉素加氨苄西林联合用药的疗效。
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Comparison of daptomycin, vancomycin, and ampicillin-gentamicin for treatment of experimental endocarditis caused by penicillin-resistant enterococci.达托霉素、万古霉素和氨苄西林-庆大霉素治疗耐青霉素肠球菌所致实验性心内膜炎的比较。
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Endocarditis Caused by Highly Penicillin-Resistant Viridans Group Streptococci: Still Room for Vancomycin-Based Regimens.由高度耐青霉素的草绿色链球菌引起的心内膜炎：万古霉素为基础的治疗方案仍有一席之地。
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Vancomycin-resistant enterococcus infection in the hematopoietic stem cell transplant recipient: an overview of epidemiology, management, and prevention.造血干细胞移植受者中的耐万古霉素肠球菌感染：流行病学、管理及预防概述
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本文引用的文献

1
Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faecium.氨苄西林增强达托霉素和阳离子宿主防御肽对氨苄西林和万古霉素耐药粪肠球菌的杀伤作用。
Antimicrob Agents Chemother. 2012 Feb;56(2):838-44. doi: 10.1128/AAC.05551-11. Epub 2011 Nov 28.
2
In vitro prevention of the emergence of daptomycin resistance in Staphylococcus aureus and enterococci following combination with amoxicillin/clavulanic acid or ampicillin.体外研究阿莫西林/克拉维酸或氨苄西林与达托霉素联用对金黄色葡萄球菌和肠球菌耐药性出现的预防作用。
Int J Antimicrob Agents. 2010 May;35(5):451-6. doi: 10.1016/j.ijantimicag.2009.12.022. Epub 2010 Feb 24.
3
Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study.21世纪感染性心内膜炎的临床表现、病因及转归：国际心内膜炎协作组前瞻性队列研究
Arch Intern Med. 2009 Mar 9;169(5):463-73. doi: 10.1001/archinternmed.2008.603.
4
Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster.达托霉素单药治疗由一株具有耐万古霉素和万古霉素敏感亚群的粪肠球菌引起的心内膜炎失败以及vanA基因簇体内丢失的证据。
Clin Infect Dis. 2007 Nov 15;45(10):1343-6. doi: 10.1086/522656. Epub 2007 Oct 5.

Combination therapy with ampicillin and daptomycin for treatment of Enterococcus faecalis endocarditis.

作者信息

Sierra-Hoffman M, Iznaola O, Goodwin M, Mohr J

出版信息

Antimicrob Agents Chemother. 2012 Nov;56(11):6064. doi: 10.1128/AAC.01760-12. Epub 2012 Sep 10.

DOI:10.1128/AAC.01760-12
PMID:22964255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3486546/
Abstract
摘要