Benamu Esther, Deresinski Stanley
Division of Infectious Diseases, Department of Medicine, University of Colorado, Aurora, USA.
Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, USA.
F1000Res. 2018 Jan 2;7:3. doi: 10.12688/f1000research.11831.1. eCollection 2018.
Vancomycin-resistant (VRE) is now one of the leading causes of nosocomial infections in the United States. Hematopoietic stem cell transplantation (HSCT) recipients are at increased risk of VRE colonization and infection. VRE has emerged as a major cause of bacteremia in this population, raising important clinical questions regarding the role and impact of VRE colonization and infection in HSCT outcomes as well as the optimal means of prevention and treatment. We review here the published literature and scientific advances addressing these thorny issues and provide a rational framework for their approach.
耐万古霉素肠球菌(VRE)现已成为美国医院感染的主要原因之一。造血干细胞移植(HSCT)受者发生VRE定植和感染的风险增加。VRE已成为该人群菌血症的主要原因,引发了关于VRE定植和感染在HSCT结局中的作用和影响以及最佳预防和治疗方法的重要临床问题。我们在此回顾已发表的文献和针对这些棘手问题的科学进展,并为解决这些问题提供一个合理的框架。