Department of Cardiology, Fourth Military Medical University of Chinese People's Liberation Army, Xi'an, Shaanxi, China.
Chin Med J (Engl). 2012 Sep;125(18):3318-24.
To review the progress of cardiac differentiation and electrophysiological characteristics of bone marrow mesenchymal stem cells.
The databases of PubMed, Springer Link, Science Direct and CNKI were retrieved for papers published from January 2000 to January 2012 with the key words of "bone marrow mesenchymal stem cells, cardiac or heart, electrophysiology or electrophysiological characteristics".
The articles concerned cardiac differentiation and electrophysiological characteristics of bone marrow mesenchymal stem cells were collected. After excluding papers that study purposes are not coincident with this review or contents duplicated, 56 papers were internalized at last.
For the treatment of myocardial infarction and myocardiac disease, the therapeutic effects of transplantation of bone marrow mesenchymal stem cells which have the ability to develop into functional myocardial cells by lots of methods have been proved by many researches. But the arrhythmogenic effect on ventricles after transplantation of bone marrow mesenchymal stem cells derived myocardial cells is still controversial in animal models. Certainly, the low differentiation efficiency and heterogeneous development of electrical function could be the most important risk for proarrhythmia.
Many studies of cardiac differentiation of bone marrow mesenchymal stem cells have paid attention to improve the cardiac differentiation rate, and the electrophysiology characteristics of the differentiated cells should be concerned for the risk for proarrhythmia as well.
回顾骨髓间充质干细胞的心脏分化和电生理特性的研究进展。
检索 2000 年 1 月至 2012 年 1 月期间 PubMed、Springer Link、Science Direct 和中国知网（CNKI）数据库中有关骨髓间充质干细胞、心脏或心肌、电生理学或电生理特性的英文文献，选择以“bone marrow mesenchymal stem cells，cardiac or heart，electrophysiology or electrophysiological characteristics”为关键词的文章。
收集有关骨髓间充质干细胞心脏分化和电生理特性的文章。排除研究目的与本综述不一致或内容重复的文章后，最终纳入 56 篇文献。
为了治疗心肌梗死和心脏病，大量方法证明了具有向功能性心肌细胞分化能力的骨髓间充质干细胞移植的治疗效果。但骨髓间充质干细胞来源的心肌细胞移植后对心室的致心律失常作用在动物模型中仍存在争议。当然，低分化效率和电功能的异质性发育可能是致心律失常的最重要风险。
许多骨髓间充质干细胞的心脏分化研究都关注于提高心脏分化率，同时也应关注分化细胞的电生理特性，以预防致心律失常的风险。
