Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey.
Chin Med J (Engl). 2012 Sep;125(18):3349-51.
Capecitabine is an orally available chemotherapeutic agent that is converted to 5-fluorouracil (5-FU) after absorbtion. Capecitabine and its active metabolite, 5-FU, have cardiotoxic effects with reported instances of acute coronary syndromes caused due to coronary vasospasm. However, these agents exert toxic effects on cardiovascular system and beyond vasospasm provacation. We report a 46-year-old patient diagnosed as acute inferior infarction who is treated with capecitabine for 3 months due to metastatic breast carcinoma, in whom thrombotic coronary occlusion was observed in angiography. This case demonstrates that apart from vasospasm, coronary thrombosis could be observed after capecitabine treatment, with a possible direct effect of this drug.
卡培他滨是一种口服化疗药物，吸收后转化为 5-氟尿嘧啶（5-FU）。卡培他滨及其活性代谢物 5-FU 具有心脏毒性作用，有报道称因冠状动脉痉挛引起急性冠状动脉综合征。然而，这些药物除了引起血管痉挛外，还会对心血管系统及其他系统产生毒性作用。我们报告了 1 例 46 岁的患者，诊断为急性下壁梗死，因转移性乳腺癌接受卡培他滨治疗 3 个月，在该患者的血管造影中观察到血栓性冠状动脉闭塞。本例表明，除血管痉挛外，卡培他滨治疗后还可能观察到冠状动脉血栓形成，这可能是该药物的直接作用。
