Capital Epilepsy Therapy Center, Department of Neurosurgery, First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing, China.
Pediatr Neurol. 2012 Oct;47(4):284-90. doi: 10.1016/j.pediatrneurol.2012.06.014.
The pediatric epileptic spectrum and seizure control in surgical patients have been defined in developed countries. However, corresponding data on school-aged children from developing countries are insufficient. We summarized epileptic surgical data from four centers in China, to compare surgical outcomes of school-aged children with intractable partial epilepsy from China and those from developed countries, and introduce surgical candidate criteria. Data from 206 children (aged 6-14 years) undergoing surgical resection for epilepsy between September 2001 and January 2007 were selected. Postoperative freedom from seizures was achieved in 173 cases (84.0%) at 1 year, 149 (72.3%) at 3 years, and 139 (67.5%) at 5 years. Patients with focal magnetic resonance imaging abnormalities and a short history of seizure were most likely to become seizure-free postoperatively. Those with preoperative low intelligence quotients who became seizure-free postoperatively achieved improvements in full memory quotients, intelligence quotients, and overall quality of life at 2 years. Significant differences were evident in mean changes of full intelligence quotient, full memory quotient, and overall quality of life between patients with preoperative low intelligence quotients who received corpus callosotomies and those with a normal preoperative intelligence quotient, and between seizure-free children and those with continual seizures.
在发达国家，已经明确了儿科癫痫的范围和手术患者的癫痫控制情况。然而，来自发展中国家的学龄儿童的相应数据则不足。我们总结了来自中国四个中心的癫痫手术数据，旨在比较中国和发达国家学龄期儿童难治性部分性癫痫手术治疗的结果，并介绍手术候选标准。我们选取了 206 名（年龄 6-14 岁）于 2001 年 9 月至 2007 年 1 月期间接受癫痫手术切除术的患儿的数据。术后 1 年，173 例（84.0%）患儿无癫痫发作，3 年时，149 例（72.3%）患儿无癫痫发作，5 年时，139 例（67.5%）患儿无癫痫发作。具有局灶性磁共振成像异常和较短癫痫发作病史的患儿最有可能术后无癫痫发作。那些术前智商较低但术后无癫痫发作的患儿在术后 2 年时全记忆商数、智商和整体生活质量得到了提高。术前智商较低且接受胼胝体切开术的患儿和术前智商正常的患儿、无癫痫发作患儿和持续癫痫发作患儿之间，全智商、全记忆商数和整体生活质量的平均变化差异具有统计学意义。
