UK Renal Registry, Bristol, UK.
Nephron Clin Pract. 2012;120 Suppl 1:c137-43. doi: 10.1159/000342850. Epub 2012 Sep 1.
Outcome in patients treated with haemodialysis (HD) is influenced by the delivered dose of dialysis. The UK Renal Association (RA) publishes clinical practice guidelines which include recommendations for dialysis dose. The urea reduction ratio (URR) is a widely used measure of dialysis dose.
To determine the extent to which patients received the recommended dose of HD in the UK.
All seventy-two UK renal centres submitted data to the UK Renal Registry (UKRR). Two groups of patients were included in the analyses: the prevalent patient population on 31st December 2010 and the incident patient population for 2010. Centres returning data on <50% of their patient population or centres with <20 patients were excluded from centre-specific comparisons.
Data regarding URR were available from 64 renal centres in the UK. Forty nine centres provided URR data on more than 90% of prevalent patients. The proportion of patients in the UK who met the UK clinical practice guideline for URR (>65%) increased from 56% in 1998 to 86% in 2010. There was persistent variation observed between centres, with 19 centres attaining the RA clinical practice guideline in >90% of patients and 39 centres attaining the guideline in 70-90%. The overall proportion of prevalent patients with a URR >65% has continued to improve over time.
The delivered dose of HD for patients with established renal failure has increased over the last decade. Whilst the majority of UK patients achieved the target URR there was considerable variation between centres in the percentage of patients achieving the guideline.
接受血液透析 (HD) 治疗的患者的预后受透析剂量的影响。英国肾脏病协会 (RA) 发布了临床实践指南,其中包括透析剂量的建议。尿素清除率 (URR) 是广泛用于衡量透析剂量的指标。
确定英国患者接受推荐剂量 HD 的程度。
英国所有 72 个肾脏中心向英国肾脏登记处 (UKRR) 提交数据。分析中包括两组患者:2010 年 12 月 31 日的现患患者人群和 2010 年的新发病例患者人群。未返回其患者人群<50%数据或<20 名患者的中心被排除在中心特定比较之外。
英国 64 个肾脏中心提供了 URR 数据。49 个中心提供了超过 90%现患患者的 URR 数据。符合英国临床实践指南 URR (>65%)的患者比例从 1998 年的 56%增加到 2010 年的 86%。中心之间仍存在持续的差异,19 个中心>90%的患者达到 RA 临床实践指南,39 个中心达到 70-90%的患者达到指南。URR>65%的现患患者比例总体上随着时间的推移而持续提高。
过去十年中,终末期肾衰竭患者接受的 HD 剂量有所增加。虽然大多数英国患者达到了目标 URR,但中心之间达到指南的患者比例存在很大差异。