无毛促进 PPARγ 的表达，是白色脂肪生成所必需的。
Hairless promotes PPARγ expression and is required for white adipogenesis.
机构信息
Institute of Cell Biology, ETH Zurich, Zurich 8093, Switzerland.
出版信息
EMBO Rep. 2012 Nov 6;13(11):1012-20. doi: 10.1038/embor.2012.133. Epub 2012 Sep 11.
Abstract
Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non-adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the expression of PPARγ, one of the central adipogenic transcription factors. In conclusion, our data provide a new mechanism required for white adipogenesis.
摘要
脂肪组织是哺乳动物体内储存脂肪作为能量的最大器官，为维持全身能量平衡提供了重要的燃料储备。在这里，我们发现转录共激活因子无毛（HR）是白色脂肪生成所必需的。此外，在允许的条件下，HR 在非脂肪生成前体细胞中的强制表达诱导脂肪生成基因表达并增强脂肪细胞形成。HR 通过调节中央脂肪生成转录因子之一 PPARγ 的表达发挥其促进脂肪生成的作用。总之，我们的数据提供了白色脂肪生成所必需的新机制。
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