Department of Molecular Biology, Yale University, 219 Prospect St., New Haven, CT 06520, USA.
Cell. 2011 Sep 2;146(5):761-71. doi: 10.1016/j.cell.2011.07.019.
In mammalian skin, multiple types of resident cells are required to create a functional tissue and support tissue homeostasis and regeneration. The cells that compose the epithelial stem cell niche for skin homeostasis and regeneration are not well defined. Here, we identify adipose precursor cells within the skin and demonstrate that their dynamic regeneration parallels the activation of skin stem cells. Functional analysis of adipocyte lineage cells in mice with defects in adipogenesis and in transplantation experiments revealed that intradermal adipocyte lineage cells are necessary and sufficient to drive follicular stem cell activation. Furthermore, we implicate PDGF expression by immature adipocyte cells in the regulation of follicular stem cell activity. These data highlight adipogenic cells as skin niche cells that positively regulate skin stem cell activity, and suggest that adipocyte lineage cells may alter epithelial stem cell function clinically.
在哺乳动物的皮肤中，多种类型的常驻细胞对于构建功能性组织和支持组织稳态及再生是必需的。构成皮肤稳态和再生的上皮干细胞龛的细胞尚未得到很好的定义。在这里，我们在皮肤中鉴定出脂肪前体细胞，并证明它们的动态再生与皮肤干细胞的激活平行。对脂肪生成缺陷的小鼠和移植实验中的脂肪细胞谱系细胞的功能分析表明，真皮内脂肪细胞谱系细胞是激活毛囊干细胞所必需的且充分的。此外，我们还表明幼稚脂肪细胞中 PDGF 的表达参与调节毛囊干细胞的活性。这些数据突出了成脂细胞作为皮肤生态位细胞，正向调节皮肤干细胞的活性，并提示脂肪细胞谱系细胞可能在临床上改变上皮干细胞的功能。
