Kotagal Vikas, Bohnen Nicolaas I, Müller Martijn L T M, Koeppe Robert A, Frey Kirk A, Albin Roger L
Arch Neurol. 2012 Dec;69(12):1628-31. doi: 10.1001/archneurol.2012.764.
BACKGROUND Prior studies suggest that serotoninergic neurotransmission reduces β-amyloid (Aβ) production. OBJECTIVE To determine whether serotoninergic system degeneration in Parkinson disease promotes Aβ deposition, using in vivo positron emission tomographic probes of serotonin system integrity and Aβ deposition. DESIGN, SETTING, AND PATIENTS Cross-sectional study of 13 subjects with Parkinson disease from the movement disorders clinics at the University of Michigan Health System and Veterans Affairs Ann Arbor Healthcare System, with positron emission tomography using the serotonin transporter ligand carbon 11 ([11C])-labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitrile (DASB) and the Aβ ligand [11C]Pittsburgh compound B. RESULTS Inverse correlations were found between DASB and Pittsburgh compound B distribution volume ratios in the neocortex (ρ = -0.577; P = .04) and striatum (ρ = -0.780; P = .002). CONCLUSION Serotoninergic system degeneration in Parkinson disease may promote the development of cerebral amyloidopathy.
背景 先前的研究表明，5-羟色胺能神经传递可减少β-淀粉样蛋白（Aβ）的产生。目的 使用5-羟色胺系统完整性和Aβ沉积的体内正电子发射断层扫描探针，确定帕金森病中5-羟色胺能系统退化是否会促进Aβ沉积。设计、地点和患者 对来自密歇根大学卫生系统运动障碍诊所和退伍军人事务安阿伯医疗保健系统的13名帕金森病患者进行横断面研究，采用正电子发射断层扫描，使用5-羟色胺转运体配体碳11（[11C]）标记的3-氨基-4-（2-二甲基氨基甲基-苯基硫基）-苯甲腈（DASB）和Aβ配体[11C]匹兹堡化合物B。结果 在新皮层（ρ = -0.577；P = .04）和纹状体（ρ = -0.780；P = .002）中，发现DASB与匹兹堡化合物B分布体积比之间呈负相关。结论 帕金森病中5-羟色胺能系统退化可能促进脑淀粉样病变的发展。
