Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi, Japan.
Ophthalmic Plast Reconstr Surg. 2012 Sep-Oct;28(5):376-81. doi: 10.1097/IOP.0b013e31825e6a88.
To clarify the causative factor of Asian double eyelid.
Experimental anatomic study.
Twenty-six upper eyelids (13 right and 13 left) from 17 Japanese cadavers (9 males and 8 females, mean age at death: 73.1 years).
The specimens, obtained from the central part of the upper eyelids, were dehydrated, embedded in paraffin, cut into 7-μm thick slices and stained with Masson trichrome. Statistical analysis was based on the Mann-Whitney U test. Statistical significance was defined as p < 0.05.
Orbicularis oculi muscle thickness and shape, with or without the levator extension, orbicularis oculi muscle bundle spacing, thickness of upper eyelid skin and subcutaneous tissue, fusional site between the levator aponeurosis and the orbital septum, with or without inferior drooping of fat tissue.
The orbicularis muscle was thinner at the skin crease of a double eyelid than at 10 mm from the eyelid margin in the single eyelid group (p = 0.029). In 3 specimens the skin crease of double eyelid was at the tip of the bending orbicularis muscle, which was thick. Although the skin crease in the region of a double eyelid was thinner than in other parts of the skin, excluding the simple crease regions, other outcome measures were not shown as definite causative factors in creating the Asian double eyelid.
The thickness of orbicularis oculi muscle or its bending shape, and the thickness of the skin at the skin crease, are major causative factors in Asian double eyelid formation.
阐明亚洲人双眼皮的成因。
实验解剖学研究。
17 具日本尸体的 26 个上眼睑（13 个右眼和 13 个左眼）（9 名男性和 8 名女性，死亡时的平均年龄：73.1 岁）。
从眼睑中部获得的标本经过脱水、石蜡包埋、切成 7μm 厚的切片并用 Masson 三色染色。统计分析基于 Mann-Whitney U 检验。统计学意义定义为 p<0.05。
眼轮匝肌的厚度和形状，是否有提肌延伸，眼轮匝肌束的间隔，上眼睑皮肤和皮下组织的厚度，提上睑肌腱膜与眶隔的融合部位，是否有脂肪组织的下塌。
在单眼皮组中，双眼皮的皮肤褶皱处的眼轮匝肌比距睑缘 10mm 处的眼轮匝肌薄（p=0.029）。在 3 个标本中，双眼皮的皮肤褶皱位于弯曲的眼轮匝肌的尖端，该处较厚。尽管双眼皮区域的皮肤褶皱比其他部位的皮肤薄，但除了单纯的褶皱区域外，其他结果指标并未被确定为形成亚洲双眼皮的明确成因。
眼轮匝肌的厚度或其弯曲形状，以及皮肤褶皱处的皮肤厚度，是形成亚洲双眼皮的主要成因。
