Cabrerizo-García José Luis, Sebastián-Royo Mariano, Montes Nerea, Zalba-Etayo Begoña
Internal Medicine Service, Defense General Hospital, Zaragoza, Spain.
Sao Paulo Med J. 2012;130(4):259-62. doi: 10.1590/s1516-31802012000400010.
Decreased vitamin B12 concentration does not usually result in clinical or hematological abnormalities. Subacute combined spinal cord degeneration and pancytopenia are two serious and rarely displayed consequences that appear in severe deficits.
We present the case of a patient with subacute combined spinal cord degeneration and pancytopenia secondary to severe and sustained vitamin B12 deficiency. Such cases are rare nowadays and have potentially fatal consequences.
Vitamin B12 deficiency should be taken into consideration in the differential diagnosis in cases of blood disorders or severe neurological symptoms. Early diagnosis and treatment can avoid irreversible consequences.
维生素B12浓度降低通常不会导致临床或血液学异常。亚急性联合变性和全血细胞减少是严重缺乏时出现的两种严重且罕见的后果。
我们报告一例继发于严重且持续维生素B12缺乏的亚急性联合变性和全血细胞减少患者。如今此类病例罕见且可能导致致命后果。
在血液系统疾病或严重神经症状的鉴别诊断中应考虑维生素B12缺乏。早期诊断和治疗可避免不可逆转的后果。