Furubayashi Nobuki, Nakamura Motonobu, Nishiyama Keniti, Hasegawa Yoshihiro
Department of Urology, National Kyushu Cancer Center, Fukuoka 811-1395, Japan.
Oncol Lett. 2010 Jan;1(1):41-44. doi: 10.3892/ol_00000007. Epub 2010 Jan 1.
In order to demonstrate the original and infiltrating patterns of prostatic carcinoma, the change of histological characteristics associated with increasing total cancer volume was investigated. Tissue specimens from 196 histopathological cases, obtained at the Kyushu Cancer Center, were reviewed in embedded whole-mount antegrade radical prostatectomy specimens with adenocarcinoma. Three groups (<0.5 cm(3), ≤0.5 cm(3) <1 cm(3) and ≥1 cm(3)) of total cancer volume were identified and a histological study on each group was conducted based on the 2005 International Society of Urological Pathology Consensus Conference on Gleason Grading of Prostatic Carcinoma. With a cancer volume of <0.5 cm(3), Gleason primary patterns 3 and 4 were observed in 64.4 and 26.7% of the tumors, respectively, while Gleason secondary patterns 3 and 4 were observed in 53.3 and 42.2%, respectively. The density of the acini was much higher in comparison with that of ambient normal acini. The percentage of acini, including cribriform carcinoma classified as Gleason pattern 3, increased significantly with the increase of cancer volume (p<0.01). The original pattern of the prostatic carcinoma was histologically composed of small acini of Gleason patterns 3 and 4 without forming a cribriform pattern. In addition, prostatic carcinoma infiltrated the surrounding stroma at a very early stage, thus infiltrating not only the stroma but also the preexisting ducts and acini, causing an increased cancer volume.
为了阐明前列腺癌的原发和浸润模式，研究了与癌总体积增加相关的组织学特征变化。对在九州癌症中心获取的196例组织病理学病例的组织标本进行回顾，这些标本来自前列腺腺癌的嵌入式全层顺行根治性前列腺切除术标本。确定了癌总体积的三组（<0.5 cm³、≤0.5 cm³<1 cm³和≥1 cm³），并根据2005年国际泌尿病理学会前列腺癌Gleason分级共识会议对每组进行组织学研究。癌体积<0.5 cm³时，分别有64.4%和26.7%的肿瘤观察到Gleason主要模式3和4，而分别有53.3%和42.2%观察到Gleason次要模式3和4。与周围正常腺泡相比，腺泡密度要高得多。归类为Gleason模式3的筛状癌腺泡百分比随癌体积增加而显著增加（p<0.01）。前列腺癌的原发模式在组织学上由Gleason模式3和4的小腺泡组成，未形成筛状模式。此外，前列腺癌在极早期就浸润周围基质，不仅浸润基质，还浸润先前存在的导管和腺泡，导致癌体积增加。
