Gu Feng, Ma Yongjie, Fan Yu, Lang Ronggang, Ding Ting, Hao Xishan, Gong Yun, Kobayahsi Hisayuki, Fang Zhiwei, Fu Li
Anti-tumor Drug Sensitivity Test Lab, Department of Breast Cancer Pathology and Research Laboratory, Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Key Laboratory of Cancer Prevention and Therapy of Tianjin.
Oncol Lett. 2010 Sep;1(5):885-888. doi: 10.3892/ol_00000157. Epub 2010 Sep 1.
The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28-year old man presented at our hospital with a large mass in his right shank which had a hard texture and an obscure boundary. The histopathological diagnosis of excisional biopsy specimens was synovial sarcoma with low differentiation. Theprubicin/Cisplatin (THP/CDDP) neoadjuvant chemotherapy was selected based on the results obtained from the CD-DST. After three courses, a computed tomography (CT) scan was performed which indicated that the volume of the tumor had decreased significantly. Additionally, tumor necrosis, as well as the clinical response, showed complete response. The histopathological diagnosis of wide excision specimens indicated a grade III chemotherapy response. The patient was alive and without recurrence after a follow-up of 16 months. Our results indicated that the CD-DST is a useful tool for selecting neoadjuvant chemotherapeutic drugs for patients with synovial sarcoma.
胶原凝胶微滴包埋培养-药物敏感性试验（CD-DST）是大约10年前开发的一种抗癌药物敏感性试验。本研究报告了该试验在一名右小腿巨大滑膜肉瘤患者新辅助化疗药物选择中的应用。一名28岁男性因右小腿出现质地硬、边界不清的巨大肿块前来我院就诊。切除活检标本的组织病理学诊断为低分化滑膜肉瘤。基于CD-DST的结果选择了吡柔比星/顺铂（THP/CDDP）新辅助化疗。三个疗程后，进行了计算机断层扫描（CT），结果显示肿瘤体积显著减小。此外，肿瘤坏死以及临床反应均显示完全缓解。广泛切除标本的组织病理学诊断显示化疗反应为Ⅲ级。随访16个月，患者存活且无复发。我们的结果表明，CD-DST是为滑膜肉瘤患者选择新辅助化疗药物的有用工具。
